α-吡啶甲酸铬配合物与EHPG作用的光谱研究  

The Synthesis of Chromium Picolinate and Its Interaction with EHPG

作　　者：辛先荣[1] 王志鹏[1] 杨斌盛[1] 

机构地区：[1]山西大学分子科学研究所,山西太原030006

出　　处：《山西大学学报（自然科学版）》2004年第2期167-169,共3页Journal of Shanxi University(Natural Science Edition)

基　　金：山西省自然科学基金 (No.2 0 0 310 17)

摘　　要：由α-吡啶甲酸和 Cr Cl3· 6 H2 O合成了α-吡啶甲酸铬配合物 (Cr(C6 H4 NO2 ) 3· 1/ 2 H2 O) ,用红外光谱、紫外 -可见吸收光谱、荧光光谱、元素分析表征了配合物结构 .在 p H7.4、0 .1mol/ L Hepes条件下 ,以 EHPG为转铁蛋白模拟物 ,观察了铬 ( )由α-吡啶甲酸铬配合物向 Cr-Chromium picolinate was prepared from chromium chloride and picolinic acid.The structure of the complex was characterized by UV-Vis,IR,fluorescent spectroscopy,and elementary analyis.Using EHPG as mimic molecular of human serum apotransferrin,the kinetics of chromium transfer from chromium picolinate to Cr-EHPG was investigated at 0.1 mol/L Hepes,pH 7.4 by fluorescent spectroscopy.The k_(obs) was 0.026 h^(-1).

关 键 词：α-吡啶甲酸铬配合物 EHPG 光谱 葡萄糖耐受因子 胰岛素 降血糖作用 

分 类 号：R914.4[医药卫生—药物化学] O614.812[医药卫生—药学]