放射治疗增敏的新靶点ATM的研究进展  

Advances in research on ATM as a target for novel radiosensitizers

作　　者：杨劲松[1] 陆雪官[1] 冯炎[2] 

机构地区：[1]苏州大学附属第二医院放射治疗科,江苏苏州215004 [2]复旦大学附属肿瘤医院放射治疗科,上海200032

出　　处：《中国癌症杂志》2004年第2期187-189,193,共4页China Oncology

摘　　要：临床发现患遗传性共济失调-毛细血管扩张(ataxia-telangiectasia,A-T)综合征的患者对电离辐射具有高敏感性。通过研究表明其高放射敏感性可能归因于ATM(ataxia-telangiectasia mutated)基因,其中起关键作用的部分是ATM蛋白激酶。为此,人们开发了ATM激酶的阻滞剂,如咖啡因、己酮可可碱、甲基黄嘌呤和UCN-01(7-hydroxystaurosporine)等,并在基础和临床研究中获得了一些可喜的结果。Patients with ataxia-telangiectasia ( A-T) syndrome were charachaterized by profound hypersensitivity to ionizing radiation in clinic. Many studies have shown that this hypersensitivity possibly attributed to ATM gene whose critical compartment was ATM kinase. So inhibitors of the ATM kinase such as caffeine, pentoxifylline, methyl xanthines and 7-hydroxystaurosporine (UCN-01) were developed and have achieved a few encouraging results in basic and clinical stuides.

关 键 词：放射治疗 放射增敏剂 ATM基因 A-T综合症 

分 类 号：R730.55[医药卫生—肿瘤]