小分子玉米肽Leu-Asp-Tyr-Glu保护线粒体抗氧化损伤的研究  

Protection of Small Molecule Corn Peptide Leu-Asp-Tyr-Glu from Mitochondria Against Oxidative Damage

作　　者：徐力[1] 李相鲁[1] 黄宜兵[1] 吴晓霞[1] 侯瑞珍[1] 王华[2] 王娜[1] 张学忠[1] 

机构地区：[1]吉林大学分子酶学工程教育部重点实验室,长春130023 [2]吉林大学中日联谊医院,长春130031

出　　处：《高等学校化学学报》2004年第6期1073-1075,共3页Chemical Journal of Chinese Universities

基　　金：国家"十五"科技攻关计划项目 (批准号 :2 0 0 1BA747C)资助

摘　　要：A small molecule peptide Leu-Asp-Tyr-Glu(LDYE) prepared from the enzymatic hydrolysate of zein was tested for its anti-oxidative activities. The effects of LDYE on the turgidity of mitochondria,the fluidity of membrane,the activity of cytochrome C oxidase and ATPase at subcellular level were investigated by using H\-2O\-2/Fe\+\{2+\} -induced mitochondria damage model system. It was found that the small peptide exhibited an obvious ability of removing free radicals and protecting the mitochondria from damage by oxidation. [WT5HZ]A small molecule peptide Leu-Asp-Tyr-Glu(LDYE) prepared from the enzymatic hydrolysate of zein was tested for its anti-oxidative activities. The effects of LDYE on the turgidity of mitochondria,the fluidity of membrane,the activity of cytochrome C oxidase and ATPase at subcellular level were investigated by using H\-2O\-2/Fe\+\{2+\} -induced mitochondria damage model system. It was found that the small peptide exhibited an obvious ability of removing free radicals and protecting the mitochondria from damage by oxidation. [WT5HZ]

关 键 词：玉米肽 线粒体 抗氧化活性 

分 类 号：Q514[生物学—生物化学]