中国新疆维吾尔族人群与汉族人群FUT2基因结构的比较研究  

Study about the FUT2 gene structure of Xinjiang Uighur and Han nationality

作　　者：魏天莉[1] 吴国光[1] 苏宇清[1] 金士正[1] 周丹[1] 

机构地区：[1]广东省深圳市输血医学研究所,518035

出　　处：《广东医学》2004年第5期514-515,共2页Guangdong Medical Journal

基　　金：广东省医学科研基金立项课题 (编号 :B2 0 0 2 111) ;深圳市卫生局科技立项项目 (编号 :2 0 0 2 0 42 18)

摘　　要：目的　探讨中国新疆地区维吾尔族和汉族人群的FUT2基因分子结构。方法　对 4 0例的维吾尔族和 4 1例汉族人群随机供者血样进行DNA抽提 ,并进行FUT2基因测序分析。结果　共发现维吾尔族人群的FUT2有 35 7,385 ,4 2 8,739四处位置上存在突变。它们的基因频率分别为 :35 7T =71 2 5 % ,35 7C =2 8 75 % ,385A =77 5 0 % ,385T =2 2 5 0 % ,4 2 8G =70 % ,4 2 8A =30 % ,739G =72 5 0 % ,739A =2 7 5 0 %。中国汉族人群的FUT2基因不存在 4 2 8和 739两处突变 ,但是存在 35 7和 385两处位置的突变。它们的基因频率分别为 :35 7T =90 2 4 % ,35 7C =9 76 % ,385A =5 8 5 4 % ,385T =4 1 4 6 %。结论　根据中国新疆维吾尔族人群的FUT2基因结构的特点 。ObjectiveThe Secretor gene(FUT2) encodes the enzyme alpha(1,2) fucosyltransferase that determines the expression of ABO(H) antigens in secretions. FUT2 gene exhibits polymorphism that related to race. We study the molecular structure of FUT2 gene in Uighur population in Xinjiang area and Chinese with Han nationality. MethodsDNA was extracted from 40 Uighur and 41 Han unrelated donor blood. FUT2 gene of the DNA samples was studied by sequencing.ResultsFour mutations in the FUT2 gene of Uighur donors were identified. The frequencies of mutations were 71 25% for 357T, 28 75% for 357C,77 50% for 385A,22 50% for 385T,70% for 428G,30% for 428A,72 50% for 739G and 27 50% for 739A,respectively. There were two mutations in the FUT2 gene of Han donors. The frequencies of mutations were 90 24% for 357T, 9 76% for 357C,58 54% for 385A and 41 46% for 385T. ConclusionThe characteristics of FUT2 gene structure of Xinjiang Uighur and Han nationality suggests that genetic polymorphism difference exist between Xinjiang Uighur and Chinese Han nationality.

关 键 词：中国 新疆维吾尔族人 汉族人 FUT2基因 基因结构 基因测序 

分 类 号：R394[医药卫生—医学遗传学]