广西扶绥县肝癌高发区和相对低发区儿童黄曲霉毒素B1摄入量对比研究  

A STUDY OF THE INTAKES OF THE AFLATOXIN B1 DURING CHILDHOOD IN THE HIGH AND RELATIVELY LOW PLC INCIDENCE AREAS IN FUSHUI COUNTY, GUANGXI PROVINCE

作　　者：黄天壬 莫林华 徐庆芬 莫志纯[2] 刘宗河 玉太存 何振芳 涂文升 黄昭东 

机构地区：[1]广西肿瘤研究所,南宁530027 [2]广西医学院,530027 [3]扶绥肝癌研究所,532100

出　　处：《癌症》1993年第4期288-290,共3页Chinese Journal of Cancer

摘　　要：对广西扶绥县肝癌高发区和相对低发区385例5～13岁儿童的黄曲霉毒素B_1(AFB_1)摄入量进行了对比研究,结果表明,肝癌高发区儿童AFB_1摄入量明显大于相对低发区儿童(P<0.01),分别为123.51ng/kg体重/日和30.58ng/kg体重/日,前者是后者4倍多;同时,高发区儿童24小时尿中黄曲霉毒素M_1(AFM_1)排出量亦高于相对低发区儿童,分别为2.71ng/kg体重/日和1.00ng/kg体重/日(P<0.01),前者是后者两倍多。研究结果提示,该县境内出现肝癌高发区和相对低发区之差别,原因之一是不同地区居民从儿童时期起暴露于AFB_1水平不同,肝癌高发区是AFB_1高摄入量区。因此,从儿童时期起就开始注意减少AFB_1摄入量,对预防原发性肝癌有十分重要意义。This study reported the intakes of the aflatoxin B1 (AFB1) in 385 children aged 5 to 13 in the high and relatively low primary liver. Cancer (PLC) incidence areas in Fusui county, Guangxi Province. The results showed that the AFBl intake of children in high incidence region (123.51ng/kg day) is significantly higher than that in low incidence region (30 .58ng/kg day) (P<0.01). The former is four times as much as the latter. The results proved that toe AFMl average concentration in urine samples collected from high incidence region (2.71ng/kg day) is significantly higher than that found in low incidence region (1.00ng/kg day) (P<0.01). The former is twice as much as the latter. The data suggested that the difference of PLC incidence in the regions may be due to the different amount of AFBl ingested by the inhabitants in the high and low incidence areas of liver cancer during childhood In order to prevent PLC, it is of very important significance to reduce AFBl intakes during childhood

关 键 词：黄曲霉毒素 摄入量 儿童 肝肿瘤 

分 类 号：R735.702[医药卫生—肿瘤]