相转移催化不对称诱导合成α-氨基酸  

ASYMMETRIC INDUCTION IN THE SYNTHESIS OF α-AMINO ACID UNDER PTC CONDITIONS

作　　者：金春雪[1] 熊丽曾[1] 陈子康[1] 俞凌翀[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《北京师范大学学报（自然科学版）》1993年第2期224-227,共4页Journal of Beijing Normal University(Natural Science)

基　　金：国家自然科学基金

摘　　要：在固液两相体系.分别以手性和非手性季铵盐为相转移催化剂,以各种α-溴代脂肪酸薄荷醇酯为手性底物,通过与邻苯二甲酰亚胺钾的Gabriel反应,合成了4种具有光学活性的α-氨基酸,对比了在各种不对称诱导条件下产物的光学纯度.Gabriel reaction of potassium phthalimide and (-)-menthyl α-bromocarboaylates are studied under solid-liquid chiral and nonchiral PTC condi- tions. Four optically active 2-phthalimidoesters are synthesized under varied PTC con- ditions. Four L-predominant α-amino acids with optical yields 3%~13.5% are obtained by hydrazinolysis and hydrolysis of these N-substituted phthalimides.

关 键 词：氨基酸 不对称诱导 相转移催化 

分 类 号：O623.736[理学—有机化学]