抑癌基因PTEN在食管癌发生过程中的表达  

The analysis of expressions of PTEN in the occurrence of esophageal carcinomas

作　　者：王建设[1] 高新平[2] 李士瑛[3] 张新胜[4] 马克学[4] 张顺利[4] 张文学[4] 

机构地区：[1]河南师范大学体育学院,河南新乡453007 [2]新乡医学院病理教研室,河南新乡453003 [3]山西医科大学基础医学院病理教研室,山西太原030000 [4]河南师范大学生命科学学院,河南新乡453007

出　　处：《河南师范大学学报（自然科学版）》2004年第2期76-78,共3页Journal of Henan Normal University(Natural Science Edition)

摘　　要：目的:探讨PTEN基因表达在食管癌发生过程中的变化及作用.方法:采用SP免疫组织化学方法检测50例原发性食管鳞状上皮癌,19例单纯增生,18例非典型增生和41例正常组织中PTEN基因的表达,结合临床病理资料进行分析.结果:癌组织中PTEN的表达与正常组织相比差异极显著(P<0.001),与单纯增生和非典型增生组织之间差异显著(P<0.05).结论:在食管癌的发生过程中,PTEN基因起一定的作用.Objective: To investigate the expressions of PTEN gene in esophageal squamous cell carcinoma and whether the PTEN gene is associated with occurrence and progression of esophageal carcinomas. Method:The expressions of tumor suppressor gene PTEN in 50 samples with primary esophageal squamous cell carcinoma(SCC), 19 samples with basal cell hyperplasia(BCH), 18 samples with dysplasia(DYS) and 41 samples with normal epithelia were comparatively studied with immunohistochemical method. Result: PTEN positive expression rate in SCC was very significantly lower than that in normal epithelia (P<0.001), and dramatically lower than that in BCH and DYS (P<0.05). The results suggest that PTEN gene plays an important role in occurrence and progression of esophageal squamous cell carcinoma.

关 键 词：PTEN基因 抑癌基因 食管鳞状上皮癌 

分 类 号：R735.1[医药卫生—肿瘤]