过敏性紫癜患儿血清可溶性CTLA-4表达变化与临床意义  

Changes of Soluble Cytotoxic T-Lymphocyte-Associated Antigen-4 in Children with Henoch-Schonlein Purpura and Its Clinical Significance

作　　者：董玉珍 李云[1] 谭好飞 张秋业[1] 

机构地区：[1]青岛大学附属医院儿科,山东青岛 [2]青岛大学附属医院,山东青岛

出　　处：《临床医学进展》2019年第9期1062-1067,共6页Advances in Clinical Medicine

摘　　要：目的:探讨过敏性紫癜(Henoch-Schonlein Purpura, HSP)患儿急性期血清可溶性细胞毒性T细胞相关抗原-4 (sCTLA-4)的水平变化及意义。方法:选择2017年12月至2018年5月期间住院治疗的HSP患儿49例为研究对象(HSP组),62名健康儿童为正常对照组(对照组),应用双抗体夹心法酶联免疫吸附试验(ELISA)检测HSP患儿和对照组儿童血清sCTLA-4的浓度。结果:HSP组患儿急性期血清sCTLA-4水平为(3749.5 ±804.5) pg/ml;明显低于对照组[(5101.8 ±566.7) pg/ml],差异有显著统计学意义(P 0.05),有/无早期肾损害的HSP组患儿血清sCTLA-4水平分别为(3801.6 ±839.7) pg/ml和(3724.3 ±799.0) pg/ml,急性期有/无消化道症状的HSP患儿血清sCTLA-4水平分别为(3927.8 ±242.3) pg/ml和(3670.9 ±126.9) pg/ml (P >0.05),各组间差异均无统计学意义(P均 >0.05)。HSP组患儿急性期血清sCTLA-4水平与免疫球蛋白IgA、IgG、IgM、IgE水平间均无明显相关性(r = ?0.172~0.187,P均 >0.05)。结论:HSP患儿急性期血清sCTLA-4水平降低,T细胞抑制信号不足,提示sCTLA-4在儿童HSP的发病机制中可能发挥一定作用。Objective:To investigate the changes and significance of serum soluble cytotoxic t-cell-associated antigen-4(sCTLA-4)in patients with Henoch-Schonlein purpura(HSP)in acute phase.Methods:49 children hospitalized with HSP from December 2017 to May 2018 were selected as study subjects(HSP group),and 62 healthy children were selected as normal control group(control group).Serum sCTLA-4 concentrations of children with HSP and control group were detected by double-antibody sandwich ELISA.Results:The serum sCTLA-4 level in HSP group was(3749.5±804.5)pg/ml.It was significantly lower than the control group[(5101.8±566.7)pg/ml],and the difference was statistically significant(P 0.05),respectively.Serum sCTLA-4 levels in children with/without early renal damage in the HSP group were(3801.6±839.7)pg/ml and(3724.3±799.0)pg/ml,respectively.Serum sCTLA-4 levels of HSP children with/without gastrointestinal symptoms in the acute phase were(3927.8±242.3)pg/ml and(3670.9±126.9)pg/ml(P>0.05),respectively,and there was no statistically significant difference between each group(all P>0.05).There was no significant correlation between serum sCTLA-4 levels and immunoglobulin IgA,IgG,IgM,IgE levels in HSP group(r=?0.172-0.187,all P>0.05).Conclusion:Serum sCTLA-4 level in children with HSP in acute phase is reduced,and T cell inhibition signal is insufficient,suggesting that sCTLA-4 may play a certain role in the pathogenesis of HSP in children.

关 键 词：过敏性紫癜 细胞毒性T细胞相关抗原-4 血清 儿童 

分 类 号：R73[医药卫生—肿瘤]