融合基因在儿童急性淋巴细胞白血病中的临床意义  

The Clinical Significance of Fusion Gene in Childhood with Acute Lymphoblastic Leukemia

作　　者：康慧 郝国平[2] 

机构地区：[1]山西医科大学儿科医学系,山西 太原 [2]山西省儿童医院血液科,山西 太原

出　　处：《临床医学进展》2020年第5期801-810,共10页Advances in Clinical Medicine

摘　　要：急性淋巴细胞白血病是最常见的儿童血液肿瘤,由于分层诊疗、免疫治疗以及骨髓移植等方法的应用,儿童急性淋巴细胞白血病的生存率明显增高。融合基因是儿童急性白血病常见的遗传学异常,其在急性白血病的发生发展、诊疗预后等方面有重要意义。本文总结了儿童急性淋巴细胞白血病中出现的部分融合基因,就其在儿童急性淋巴细胞白血病的发生发展、辅助诊断、指导治疗、疗效评估、预后预测等方面的临床意义进行综述。Acute lymphoblastic leukemia is the most common malignant tumor of children's blood system. Because of the application of stratified diagnosis and treatment, immunotherapy and bone marrow transplantation, the survival rate of children with acute lymphoblastic leukemia has significantly increased. Fusion gene is the common genetic abnormality in childhood with acute leukemia, which is of great significance in the occurrence, development, diagnosis, treatment and prognosis of acute leukemia. This report summarizes some fusion genes in childhood with acute lymphoblastic leukemia, and summarizes their clinical significance in the occurrence and development, assistant diagnosis, guiding treatment, efficacy evaluation and prognosis prediction of children with acute lymphoblastic leukemia.

关 键 词：急性淋巴细胞白血病 融合基因 儿童 

分 类 号：R73[医药卫生—肿瘤]