浅谈靶向联合免疫检查点抑制剂在HER2阳性进展期胃癌研究进展:从基础到临床  

Research Progress of Targeted Combined Immunization in HER2 Positive Advanced Gastric Cancer: From Bench to Bedside

作　　者：张雪 赵丽丽 井文君 于晓鹏 杨帅[3] 魏红梅[3] 

机构地区：[1]青岛大学医学部,山东 青岛 [2]青岛市中医医院(市海慈医院),青岛大学附属青岛市海慈医院,山东 青岛 [3]青岛大学附属青岛市中心医院,青岛市肿瘤医院,山东 青岛

出　　处：《临床医学进展》2023年第4期5864-5871,共8页Advances in Clinical Medicine

摘　　要：在中国,胃癌的发病率与死亡率均排名第三,疾病负担重。HER2阳性胃癌是胃癌的重要亚型,靶向HER2的曲妥珠单抗联合化疗能显著改善进展期胃癌患者的预后,并已成为此类晚期胃癌的一线标准治疗。免疫检查点抑制剂为主的免疫治疗是肿瘤治疗领域的研究热点,但目前临床主要应用在HER2阴性进展期胃癌中。为进一步改善HER2阳性胃癌患者预后,抗HER2靶向联合免疫检查点抑制剂在HER2阳性进展期胃癌患者中获得了初步的疗效,提示HER2阳性进展期胃癌抗HER2靶向联合免疫检查点抑制剂治疗具有深入探讨的价值。本文将现有的进展期HER2阳性胃癌主要的治疗手段——抗HER2靶向治疗以及联合免疫治疗方面,整合了临床前研究与相关临床研究的数据,对HER2阳性进展期胃癌靶向、靶向联合免疫治疗的相关研究作一综述,展望HER2阳性进展期胃癌治疗前景及方向。The incidence rate and mortality of gastric cancer rank third in China, and the disease burden is heavy. HER2 positive gastric cancer is an important subtype of gastric cancer. Trastuzumab target-ing HER2 combined with chemotherapy can significantly improve the prognosis of patients with advanced gastric cancer, and has become the first-line standard treatment of this kind of advanced gastric cancer. Immunotherapy based on immune checkpoint inhibitors is a research hotspot in the field of tumor therapy, but at present, it is mainly used in HER2 negative advanced gastric cancer. In order to further improve the prognosis of patients with HER2 positive gastric cancer, anti-HER2 targeted combined with immune checkpoint inhibitor has achieved preliminary curative effect in patients with HER2 positive advanced gastric cancer, suggesting that the treatment of anti-HER2 targeted combined with immune checkpoint inhibitor for HER2 positive advanced gastric cancer has the value of in-depth discussion. In this paper, the existing main treatment methods of ad-vanced HER2 positive gastric cancer-anti HER2 targeted therapy and combined immunotherapy, integrate the data of preclinical research and relevant clinical research, summarize the related re-search of HER2 positive advanced gastric cancer targeting and targeted combined immunotherapy, and look forward to the prospect and direction of HER2 positive advanced gastric cancer treatment.

关 键 词：胃癌 靶向治疗 免疫治疗 HER2 PD-L1 

分 类 号：R73[医药卫生—肿瘤]