蜡样芽孢杆菌毒素Cereulide的研究进展  

The Research Advances in the Toxin Cereulide Produced by Bacillus cereus

作　　者：林岚[1] 徐旭东[1] 

机构地区：[1]东南大学医学院生物工程系,江苏南京

出　　处：《微生物前沿》2018年第4期141-148,共8页Advances in Microbiology

基　　金：江苏省自然科学基金资助项目(项目号BK20151133).

摘　　要：蜡样芽孢杆菌是一种食源性条件致病菌,它能产生一种呕吐毒素cereulide和多种肠毒素;该菌引起的食物中毒在亚洲以呕吐型比较常见,致吐毒株(Bc emetic strains, Bce)在淀粉类食物和乳制品中分布较广,所致食物中毒的报道近年激增,但防治措施研究鲜有报道。通过综述蜡样芽孢杆菌毒素作用、致吐毒株的分布、cereulide生物合成与调控方面的进展,为防治该类食物中毒提供依据。Bacillus cereus (Bc), as a foodborne opportunistic pathogen, can produce a kind of emetic toxin, termed cereulide, and several enterotoxins. The emetic food poisoning caused by B. cereus is common in Asian areas. Bc emetic strains (Bce) are prevalent in starchy foods and milky products, which results in a growing body of food poisoning reports in recent years;however, few control measures have been documented. This paper summarizes the recent advances concerning the mode of actions of cereulide, the distribution of Bce, the biosynthesis of cereulide and the regulation thereof, which would provide the foundation for controlling this kind of food poisoning.

关 键 词：蜡样芽孢杆菌 呕吐毒素 生物合成 食物中毒 

分 类 号：R1[医药卫生—公共卫生与预防医学]