纳米递送系统在肿瘤免疫治疗中的应用  

Application of Nano-Delivery System in Tumor Immunotherapy

作　　者：袁豪华 李林照 聂瑛洁[2] 桂欢 

机构地区：[1]贵州大学医学院,贵州 贵阳 [2]贵州省人民医院肺部免疫疾病重点实验室,贵州 贵阳

出　　处：《纳米技术》2023年第4期97-109,共13页Hans Journal of Nanotechnology

摘　　要：免疫疗法已成为治疗癌症的有力临床策略。免疫治疗药物批准的数量一直在增加,在临床和临床前开发中出现了许多治疗方法。然而,广泛实施癌症免疫疗法的一个关键挑战仍然是免疫系统的受控调节,因为这些疗法具有严重的副作用,包括自身免疫和非特异性炎症。先进的生物材料和药物输送系统,例如纳米颗粒和使用T细胞进行治疗,可以有效地利用免疫疗法并提高其效力,同时减少毒副作用。在这里,我们讨论了这些研究进展,以及将纳米递送技术运用于肿瘤免疫治疗中机遇与挑战以及应用,以改善肿瘤免疫治疗的不足。Immunotherapy has become a powerful clinical strategy for the treatment of cancer. The number of approved immunotherapy drugs has been increasing, and many treatments have emerged in clinical and preclinical development. However, a key challenge to the widespread implementation of cancer immunotherapy remains the controlled regulation of the immune system, as these treatments have serious side effects, including autoim-munity and non-specific inflammation. Advanced biomaterials and drug delivery systems, such as nanoparticles and treatment with T cells, can effectively use immunotherapy and improve its effectiveness while reducing side effects. Here, we discuss the research progress, as well as the opportunities, challenges and applications of nano-delivery technology in tumor immunotherapy in order to improve the shortcomings of tumor immunotherapy.

关 键 词：肿瘤免疫治疗 非特异性炎症 免疫疗法 药物输送系统 药物批准 递送系统 自身免疫 毒副作用 

分 类 号：R73[医药卫生—肿瘤]