Spatial structure of beta-amyloid Aβ_(1-40) in complex with a biological membrane model  

作　　者：Konstantin SUsachev Andrey VFilippov Oleg NAntzutkin Vladimir VKlochkov 

机构地区：[1]Kazan Federal University,Kazan,Russia [2]Lulea University of Technology,Lulea,Sweden [3]Department of Physics,Warwick University,Coventry,UK

出　　处：《Advances in Alzheimer's Disease》2012年第3期22-29,共8页阿尔茨海默氏病研究进展（英文）

摘　　要：The spatial structure of beta-amyloid Aβ1-40 in complex with sodium dodecyl sulfate micelles as a model membrane system was investigated by 1H-1H two-dimensional NMR (TOCSY, NOESY) spectroscopy and molecular dynamic method calculations. On the basis of NOE and chemical shifts changes data, spatial structure of the complex beta-amyloid-model of the cell surface membrane was obtained.The spatial structure of beta-amyloid Aβ1-40 in complex with sodium dodecyl sulfate micelles as a model membrane system was investigated by 1H-1H two-dimensional NMR (TOCSY, NOESY) spectroscopy and molecular dynamic method calculations. On the basis of NOE and chemical shifts changes data, spatial structure of the complex beta-amyloid-model of the cell surface membrane was obtained.

关 键 词：1H NMR Two-Dimensional NMR (TOCSY NOESY) Spectroscopy Alzheimer’s Disease BETA-AMYLOID OLIGOPEPTIDES MICELLE 

分 类 号：O6[理学—化学]