Darier Ferrand Mammary Dermatofibrosarcoma Simulating a Breast-Type Myofibroblastoma: A Case Report  

作　　者：Michel Auguste Mouelle Sarah Gaëlle Adiang Esther Meka Michel Auguste Mouelle;Sarah Gaëlle Adiang;Esther Meka(Department of Surgery, ICANS 17 Rue Albert Calmette Strasbourg Cedex, Strasbourg, France;Fondation Médicale Adlucem, Yaoundé, Cameroon;Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon)

机构地区：[1]Department of Surgery, ICANS 17 Rue Albert Calmette Strasbourg Cedex, Strasbourg, France [2]Fondation Médicale Adlucem, Yaoundé, Cameroon [3]Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon

出　　处：《Advances in Breast Cancer Research》2023年第1期10-16,共7页乳腺癌（英文）

摘　　要：Myofibroblastoma and Darier Ferrand’s dermatofibrosarcoma are rare entities that are similar both in terms of clinical morphological characteristics and histological characteristics. We report the case of a 49-year-old non-menopausal woman with a history of right breast lumpectomy. Supported by the Chompret criteria, an oncogenetic consultation was performed. Clinical examination revealed a firm 25 mm mass on the medial part of the left breast with skin involvement. A biopsy was performed and analysis result came back in favor of a cellular type myofibroblastoma showing a fibrous component consisting of spindle cells with a herringbone arrangement. Anatomopathological results concluded to a dermatofibrosarcoma of Darier Ferrand while immunohistochemistry stated a tumor population strongly positive for CD34 expression. The search for a rearrangement of the collagen type I alpha 1 gene (COL1A1) by fluorescence in situ hybridization (FISH) was positive. The diagnosis of Dermatofibrosarcoma of Darier Ferrand can be suspected on imaging and confirmed by histology. Surgical treatment of Darier Ferrand dermatofibrosarcoma consists of wide excision of the lesions with margins greater than 2 cm, on which the prognosis mainly depends. Micrographic surgery and oncoplastic breast surgery are of major interest in this location.Myofibroblastoma and Darier Ferrand’s dermatofibrosarcoma are rare entities that are similar both in terms of clinical morphological characteristics and histological characteristics. We report the case of a 49-year-old non-menopausal woman with a history of right breast lumpectomy. Supported by the Chompret criteria, an oncogenetic consultation was performed. Clinical examination revealed a firm 25 mm mass on the medial part of the left breast with skin involvement. A biopsy was performed and analysis result came back in favor of a cellular type myofibroblastoma showing a fibrous component consisting of spindle cells with a herringbone arrangement. Anatomopathological results concluded to a dermatofibrosarcoma of Darier Ferrand while immunohistochemistry stated a tumor population strongly positive for CD34 expression. The search for a rearrangement of the collagen type I alpha 1 gene (COL1A1) by fluorescence in situ hybridization (FISH) was positive. The diagnosis of Dermatofibrosarcoma of Darier Ferrand can be suspected on imaging and confirmed by histology. Surgical treatment of Darier Ferrand dermatofibrosarcoma consists of wide excision of the lesions with margins greater than 2 cm, on which the prognosis mainly depends. Micrographic surgery and oncoplastic breast surgery are of major interest in this location.

关 键 词：MYOFIBROBLASTOMA Dermatofibrosarcoma of Darier Ferrand BREAST 

分 类 号：R73[医药卫生—肿瘤]