Oxaliplatin induced hyperexcitability syndrome in patient with appendiceal adenocarcinoma  

作　　者：Nicola Jabbour Maher Alchreiki Mohammad Hussain 

机构地区：[1]Harlan ARH Hospital, Harlan, USA [2]Hazard ARH Cancer Center, Hazard, USA [3]Johnson Medical Center, Smithfield, USA

出　　处：《Case Reports in Clinical Medicine》2013年第4期236-238,共3页临床医学病理报告（英文）

摘　　要：Oxaliplatin is a novel platinum compound with clinical activity against several solid tumors. It has been associated with sensory neuropathies and, rarely, a neuromyotonia-like hyperexcitability syndrome;a form of peripheral neuropathy manifested by tremor and twitching activity of muscles. We present a case of hyperexcitability syndrome developed during the treatment of stage III appendiceal adenocarcinoma with oxaliplatin-containing regimen and was successfully treated with Pregabalin.Oxaliplatin is a novel platinum compound with clinical activity against several solid tumors. It has been associated with sensory neuropathies and, rarely, a neuromyotonia-like hyperexcitability syndrome;a form of peripheral neuropathy manifested by tremor and twitching activity of muscles. We present a case of hyperexcitability syndrome developed during the treatment of stage III appendiceal adenocarcinoma with oxaliplatin-containing regimen and was successfully treated with Pregabalin.

关 键 词：OXALIPLATIN Peripheral Neuropathy NEUROMYOTONIA HYPEREXCITABILITY SYNDROME APPENDICEAL ADENOCARCINOMA Sodium Channels 

分 类 号：R73[医药卫生—肿瘤]