Monoarthropathy or Polyarthritis in Adolescent Japanese Girls Who Received Immunization with the Human Papillomavirus Vaccine  

作　　者：Ryuta Abe Tomomi Kinoshita Akiyo Hineno Shu-ichi Ikeda Ryuta Abe;Tomomi Kinoshita;Akiyo Hineno;Shu-ichi Ikeda(Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan)

机构地区：[1]Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan

出　　处：《Case Reports in Clinical Medicine》2016年第3期109-114,共6页临床医学病理报告（英文）

摘　　要：Joint pain or arthralgia is a common complaint among girls who have received immunization with the human papillomavirus (HPV) vaccine, but the pathogenesis of this disorder has not been completely understood. We report 2 cases of joint lesions after HPV vaccination. In one case, a 13-year-old patient showed transient arthropathy in the right wrist joint after the first dose of Gardasil^&reg administered in her left shoulder. In the other case, an 18-year-old patient had migrating joint pain with redness and swelling after the third dose of Cervarix^&reg. Her serum C-reactive protein and anti-MMP-3 levels were slightly elevated, but no autoantibodies, including rheumatoid factor and anti-CCP antibody, were detected. Although various nonsteroidal anti-inflammatory drugs produced no relief, small doses of both tacrolimus and prednisolone were highly effective for her polyarthritis. The development of reactive joint lesions after HPV vaccination was noteworthy.Joint pain or arthralgia is a common complaint among girls who have received immunization with the human papillomavirus (HPV) vaccine, but the pathogenesis of this disorder has not been completely understood. We report 2 cases of joint lesions after HPV vaccination. In one case, a 13-year-old patient showed transient arthropathy in the right wrist joint after the first dose of Gardasil^&reg administered in her left shoulder. In the other case, an 18-year-old patient had migrating joint pain with redness and swelling after the third dose of Cervarix^&reg. Her serum C-reactive protein and anti-MMP-3 levels were slightly elevated, but no autoantibodies, including rheumatoid factor and anti-CCP antibody, were detected. Although various nonsteroidal anti-inflammatory drugs produced no relief, small doses of both tacrolimus and prednisolone were highly effective for her polyarthritis. The development of reactive joint lesions after HPV vaccination was noteworthy.

关 键 词：Human Papillomavirus Vaccine Adverse Reaction ARTHRITIS ARTHRALGIA Juvenile Idiopathic Arthritis 

分 类 号：R73[医药卫生—肿瘤]