Using Linear and Non-Linear Techniques to Characterize Gait Coordination Patterns of Two Individuals with NGLY1 Deficiency  

作　　者：Charles S. Layne Dacia Martinez Diaz Christopher A. Malaya Brock Futrell Christian Alfaro Hannah E. Gustafson Bernhard Suter Charles S. Layne;Dacia Martinez Diaz;Christopher A. Malaya;Brock Futrell;Christian Alfaro;Hannah E. Gustafson;Bernhard Suter(Department of Health and Human Performance, University of Houston, Houston, TX, USA;Center for Neuromotor and Biomechanics Research, University of Houston, Houston, TX, USA;Center for Neuro Engineering and Cognitive Science, University of Houston, Houston, TX, USA;Research Center, Parker University, Dallas, TX, USA;Blue Bird Circle Rett Center, Texas Childrens Hospital, Houston, TX, USA;Baylor College of Medicine, Houston, TX, USA)

机构地区：[1]Department of Health and Human Performance, University of Houston, Houston, TX, USA [2]Center for Neuromotor and Biomechanics Research, University of Houston, Houston, TX, USA [3]Center for Neuro Engineering and Cognitive Science, University of Houston, Houston, TX, USA [4]Research Center, Parker University, Dallas, TX, USA [5]Blue Bird Circle Rett Center, Texas Childrens Hospital, Houston, TX, USA [6]Baylor College of Medicine, Houston, TX, USA

出　　处：《Case Reports in Clinical Medicine》2024年第9期391-409,共19页临床医学病理报告（英文）

摘　　要：Individuals with NGLY1 Deficiency, an inherited autosomal recessive disorder, exhibit hyperkinetic movements including athetoid, myoclonic, dysmetric, and dystonic movements impacting both upper and lower limb motion. This report provides the first set of laboratory-based measures characterizing the gait patterns of two individuals with NGLY1 Deficiency, using both linear and non-linear measures, during treadmill walking, and compares them to neurotypical controls. Lower limb kinematics were obtained with a camera-based motion analysis system and bilateral time normalized lower limb joint time series waveforms were developed. Linear measures of joint range of motion, stride times and peak angular velocity were obtained, and confidence intervals were used to determine if there were differences between the patients and control. Correlations between participant and control mean joint waveforms were calculated and used to evaluate the similarities between patients and controls. Non-linear measures included: joint angle-angle diagrams, phase-portrait areas, and continuous relative phase (CRP) measures. These measures were used to assess joint coordination and control features of the lower limb motion. Participants displayed high correlations with their control counterparts for the hip and knee joint waveforms, but joint motion was restricted. Peak angular velocities were also significantly less than those of the controls. Both angle-angle and phase-portrait areas were less than the controls although the general shapes of those diagrams were similar to those of the controls. The NGLY1 Deficient participants’ CRP measures displayed disrupted coordination patterns with the knee-ankle patterns displaying more disruption than the hip-knee measures. Overall, the participants displayed a functional walking pattern that differed in many quantitative ways from those of the neurotypical controls. Using both linear and non-linear measures to characterize gait provides a more comprehensive and nuanced characterization of NGLY1 Individuals with NGLY1 Deficiency, an inherited autosomal recessive disorder, exhibit hyperkinetic movements including athetoid, myoclonic, dysmetric, and dystonic movements impacting both upper and lower limb motion. This report provides the first set of laboratory-based measures characterizing the gait patterns of two individuals with NGLY1 Deficiency, using both linear and non-linear measures, during treadmill walking, and compares them to neurotypical controls. Lower limb kinematics were obtained with a camera-based motion analysis system and bilateral time normalized lower limb joint time series waveforms were developed. Linear measures of joint range of motion, stride times and peak angular velocity were obtained, and confidence intervals were used to determine if there were differences between the patients and control. Correlations between participant and control mean joint waveforms were calculated and used to evaluate the similarities between patients and controls. Non-linear measures included: joint angle-angle diagrams, phase-portrait areas, and continuous relative phase (CRP) measures. These measures were used to assess joint coordination and control features of the lower limb motion. Participants displayed high correlations with their control counterparts for the hip and knee joint waveforms, but joint motion was restricted. Peak angular velocities were also significantly less than those of the controls. Both angle-angle and phase-portrait areas were less than the controls although the general shapes of those diagrams were similar to those of the controls. The NGLY1 Deficient participants’ CRP measures displayed disrupted coordination patterns with the knee-ankle patterns displaying more disruption than the hip-knee measures. Overall, the participants displayed a functional walking pattern that differed in many quantitative ways from those of the neurotypical controls. Using both linear and non-linear measures to characterize gait provides a more comprehensive and nuanced characterization of NGLY1

关 键 词：NGLY1 GAIT DISABILITY KINEMATICS Angle-Angle Diagrams Phase Portraits 

分 类 号：TP2[自动化与计算机技术—检测技术与自动化装置]