A Case of Psoriasis Secondary to Tinea Corporis Treated with Skuclizumab and Review of Related Literature  

作　　者：Qingli Zou Zhou Yan Shuxian Shang Xiaolan Feng Ping Xia Xiaoyong Zhou Qingli Zou;Zhou Yan;Shuxian Shang;Xiaolan Feng;Ping Xia;Xiaoyong Zhou(School of Medicine, Jianghan University, Wuhan, China;School of Medicine, Hubei University of Chinese Medicine, Wuhan, China;Department of Dermatological, Wuhan Hospital of Integrated Traditional Chinese and Western Medicine, Wuhan, China)

机构地区：[1]School of Medicine, Jianghan University, Wuhan, China [2]School of Medicine, Hubei University of Chinese Medicine, Wuhan, China [3]Department of Dermatological, Wuhan Hospital of Integrated Traditional Chinese and Western Medicine, Wuhan, China

出　　处：《Case Reports in Clinical Medicine》2024年第12期597-603,共7页临床医学病理报告(英文)

摘　　要：The patient is a 69-year-old man with a 16-year history of psoriasis. Dermatologic examination: dry skin all over the body, head, face, trunk, and limbs can be seen widely distributed about soybean to fava bean size edematous erythema, border unclear, the surface can be seen a little flaking and scratch marks. Histopathology of skin lesions: (Abdominal) Epidermal protuberance flattened, a small number of lymphocytes, and eosinophils infiltration was seen around the capillaries in the superficial dermis. Multiple direct immunofluorescence was negative. Combined with the patient’s disease course, rash manifestations, and histopathologic findings. The diagnosis was considered: common type psoriasis. The patient was given subcutaneous injection of Skuclizumab 300 mg, and after half a month of treatment, a rash with itching appeared on the head, face, forehead, chest, hands and feet, and the symptoms of rash and itching gradually aggravated with the passage of time, and the report of fungal microscopy was positive for toenail fungus. The patient was given oral itraconazole 200 mg bid and anti-allergic drugs, topical antifungal drugs, and symptomatic support and was discharged after improvement of the condition. Six months later, the patient’s fungal microscopy was negative when he was injected with skuclizumab regularly, and the patient is still being followed up at present.The patient is a 69-year-old man with a 16-year history of psoriasis. Dermatologic examination: dry skin all over the body, head, face, trunk, and limbs can be seen widely distributed about soybean to fava bean size edematous erythema, border unclear, the surface can be seen a little flaking and scratch marks. Histopathology of skin lesions: (Abdominal) Epidermal protuberance flattened, a small number of lymphocytes, and eosinophils infiltration was seen around the capillaries in the superficial dermis. Multiple direct immunofluorescence was negative. Combined with the patient’s disease course, rash manifestations, and histopathologic findings. The diagnosis was considered: common type psoriasis. The patient was given subcutaneous injection of Skuclizumab 300 mg, and after half a month of treatment, a rash with itching appeared on the head, face, forehead, chest, hands and feet, and the symptoms of rash and itching gradually aggravated with the passage of time, and the report of fungal microscopy was positive for toenail fungus. The patient was given oral itraconazole 200 mg bid and anti-allergic drugs, topical antifungal drugs, and symptomatic support and was discharged after improvement of the condition. Six months later, the patient’s fungal microscopy was negative when he was injected with skuclizumab regularly, and the patient is still being followed up at present.

关 键 词：Skuclizumab PSORIASIS ECZEMA Fungal Infections 

分 类 号：R73[医药卫生—肿瘤]