The interaction between the dopaminergic and the serotonergic systems in the 6-OHDA rat model of Parkinson’s disease  

作　　者：Daphna Sourani Gadi Goelman 

机构地区：[1]MRI/MRS Laboratory, The Human Biology Research Center, Hadassah Hebrew University Medical Center, Jerusalem, Israel [2]MRI/MRS Laboratory, The Human Biology Research Center, Hadassah Hebrew University Medical Center, Jerusalem, Israel

出　　处：《Health》2012年第11期1218-1224,共7页健康（英文）

摘　　要：This review summarizes published results that are related to the coupling between the dopaminergic and the serotonergic systems and their association to Parkinson’s disease. We focus on the 6-hydroxydopamine rat model of Parkinson’s disease to better understand how dopamine dysfunction affects the serotonergic system, and furthermore to investigate whether a bidi-rectional coupling exists and how it affects functionality and behavior. The accumulated evidence supports a proposed mechanism for this coupling that evolves the lateral habenula.This review summarizes published results that are related to the coupling between the dopaminergic and the serotonergic systems and their association to Parkinson’s disease. We focus on the 6-hydroxydopamine rat model of Parkinson’s disease to better understand how dopamine dysfunction affects the serotonergic system, and furthermore to investigate whether a bidi-rectional coupling exists and how it affects functionality and behavior. The accumulated evidence supports a proposed mechanism for this coupling that evolves the lateral habenula.

关 键 词：Parkinson’s Disease Depression 6-HYDROXYDOPAMINE Lateral HABENULA Manganese-Enhanced-MRI 

分 类 号：R74[医药卫生—神经病学与精神病学]