Polycystic Ovary Syndrome and the Role of Metformin in Ovulation Induction  

作　　者：Fabiana Fraga Gabriel Azeredo César Salgado Romeiro Larissa Bianca Paiva Cunha de Sá Alberto Krayyem Arbex 

机构地区：[1]Endocrinology Division, IPEMED Medical School, Sã o Paulo, Brazil [2]Internal Medicine Division, Itajubá , Brazil [3]Diabetology Department, Malteser Krankenhaus St. Franziskus Hospital, Flensburg, Germany [4]Harvard T. H. Chan School of Public Health, Boston, MA, USA

出　　处：《Health》2018年第5期565-576,共12页健康（英文）

摘　　要：The Polycystic Ovary Syndrome (PCOS) is frequently associated with comorbidities such as obesity, reduced glucose tolerance, hypertension, macrovascular disease and dyslipidemia. The Metabolic syndrome occurs in 30% of women with PCOS. Metformin has increasingly been used in this therapy due to its effects in reducing insulin resistance. Treatment of PCOS aims to reduce the symptoms of hyperandrogenism, regularize the menstrual cycle, reduce metabolic abnormalities, and lower the risk of type 2 diabetes mellitus and of cardiovascular disease. Additionally it is important to prevent hyperplasia and endometrial cancer, and to offer contraception to those who do not wish pregnancy, and to help to induce ovulation to those who do. The effectiveness of metformin in this treatment is assessed in the light of the current best evidence.The Polycystic Ovary Syndrome (PCOS) is frequently associated with comorbidities such as obesity, reduced glucose tolerance, hypertension, macrovascular disease and dyslipidemia. The Metabolic syndrome occurs in 30% of women with PCOS. Metformin has increasingly been used in this therapy due to its effects in reducing insulin resistance. Treatment of PCOS aims to reduce the symptoms of hyperandrogenism, regularize the menstrual cycle, reduce metabolic abnormalities, and lower the risk of type 2 diabetes mellitus and of cardiovascular disease. Additionally it is important to prevent hyperplasia and endometrial cancer, and to offer contraception to those who do not wish pregnancy, and to help to induce ovulation to those who do. The effectiveness of metformin in this treatment is assessed in the light of the current best evidence.

关 键 词：POLYCYSTIC OVARY Syndrome METFORMIN Oral CONTRACEPTIVES FERTILITY ANOVULATION 

分 类 号：R5[医药卫生—内科学]