Objective:To investigate the changes of the AMP-activated protein kinase(AMPK)/uncoupling protein 2(UCP2)(AMPK/UCP2)pathway in ovarian granulosa cells with PCOS and its relationship with mitochondrial dysfunction.Meth...
supported by the Medical Discipine Construction Project of Pudong Health Committee of Shanghai(No.PWYgf2021-08 to S.Y.H);the National Natural Science Foundation of China(No.82030021 to W.F.X.,82070624 to C.H.L.,and 82000581 to J.P.L.)a;the Deep Blue Talent Project of Naval Medical University to W.P.X.
Autosomal dominant polycystic liver disease(ADPLD)refers to a condition characterized by the presence of numerous cholangiocytes-lined and fluid-filled cysts in the liver and the absence of polycystic kidney disease.1...
Objective To establish a conditional knockout mouse model of polycystic kidney disease 1(Pkd1)gene based on CRISPR/Cas9 and Cre-loxP gene editing technology,and to provide an animal model for in-depth research on the ...
BACKGROUND Von Meyenburg complex(VMC)(i.e.,biliary hamartoma)is a rare congenital disorder characterized by multiple dilated cystic bile ducts,without clear trends in sex or age predominance.Due to the low number of p...
Background: Polycystic ovary syndrome (PCOS) is one of the common endocrinopathies of women in the reproductive age group. Thyroid hormones have various effects on the reproductive system of female. PCOS and thyroid d...
[Objectives]To study the efficacy and safety of tanshinone capsule in the treatment of polycystic ovary syndrome(PCOS).[Methods]A randomized controlled trial or semi-randomized controlled trial of tanshinone capsule i...
Two reports of trials investigating the potential effect of acupuncture in increasing live birth rate(LBR) in women with polycystic ovary syndrome(PCOS) or those undergoing in vitro fertilization(IVF) were published b...
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, associated with chronic anovulation and hyperandrogenism. The cause of PCOS is multi-factorial and the mechanism i...
Polycystic liver disease(PLD)is a rare hereditary disease that independently exists in isolated PLD,or as an accompanying symptom of autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidn...
Background: The presence of polycystic ovarian morphology (PCO) without the other characteristics of the polycystic ovarian syndrome (PCOS) is insufficient for the diagnosis of PCOS and there is little justification f...