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The ABC transporter SmABCG1 mediates tanshinones export from the peridermic cells of Salvia miltiorrhiza root: 《Journal of Integrative Plant Biology》2025年第1期135-149,共15页Yajing Li Junfeng Chen Jingyu Zhi Doudou Huang Yuchen Zhang Lei Zhang Xinyi Duan Pan Zhang Shi Qiu Jiaran Geng Jingxian Feng Ke Zhang Xu Yang Shouhong Gao Wenwen Xia Zheng Zhou Yuqi Qiao Bo Li Qing Li Tingzhao Li Wansheng Chen Ying Xiao; financially supported by the National Key Research and Development Program of China(2022YFC3501700);the National Natural Science Foundation of China(82304662,82374159,32070327,32170402);the National Key Research and Development Program of China(2023YFC3504800);Chenguang project of Shanghai(23CGA52);Science and Technology Development Program of Shanghai University of Traditional Chinese Medicine(23KFL051);Shanghai Municipal Science and Technology Commission(23XD1423500)。; Plants have mechanisms to transport secondary metabolites from where they are biosynthesized to the sites where they function,or to sites such as the vacuole for detoxification.However,current research has mainly focu...; 关键词：ATP-binding cassette transporter biosynthesis gene cluster CYTOTOXICITY EXPORT peridermic cells TANSHINONE

Tanshinone ⅡA improves Alzheimer’s disease via RNA nuclearenriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis被引量：2: 《World Journal of Psychiatry》2024年第4期563-581,共19页Long-Xiu Yang Man Luo Sheng-Yu Li; Supported by 2020 Guangxi Zhuang Autonomous Region Health Care Commission Self-Financing Research Projects,No.Z20200096;2023 Guangxi University Young and Middle-Aged Teachers’Basic Research Ability Improvement Project,No.2023KY0091;National Natural Science Foundation of China,No.82260241;the Natural Science Foundation of Guangxi Province,No.2015GXNSFAA139171 and No.2020GXNSFAA259053.; BACKGROUND Alzheimer’s disease(AD)is a neurodegenerative condition characterized by oxidative stress and neuroinflammation.Tanshinone ⅡA(Tan-ⅡA),a bioactive compound isolated from Salvia miltiorrhiza plants,has sho...; 关键词：TanshinoneⅡA Alzheimer’s disease Nuclear-enriched abundant transcript 1 Member of RAS oncogene family Rab22a Reactive oxygen species

Reconstruction of Postinfarcted Cardiac Functions Through Injection of Tanshinone ⅡA@Reactive Oxygen Species-Sensitive Microspheres Encapsulated in a Thermoreversible Hydrogel被引量：1: 《Energy & Environmental Materials》2024年第2期187-199,共13页Ling Yu Yubin Liang Lei Gao Peipei Chen Zhiqiang Yu Minzhou Zhang Aleksander Hinek Shuai Mao; supported by the National Natural Science Foundation of China(82104962,82104647,82274271);Scientific Research Project of Guangdong Provincial Administration of Traditional Chinese Medicine(20211070);Science and Technology Planning Project of Guangzhou(202102010301);Young Talents Support Project from China Association of Chinese Medicine(2019-QNRC2-C06);Team of Prevention and Treatment of Acute Myocardial Infarction with Chinese Medicine(2019KCXTD009); Myocardial damage resulting from acute myocardial infarction often leads to progressive heart failure and sudden death,highlighting the urgent clinical need for effective therapies.Recently,tanshinoneⅡA has been iden...; 关键词：myocardial infarction ROS-sensitive polymer tanshinoneⅡA thermoreversible hydrogel ventricular remodeling

Two-step continuous flow process of sodium tanshinone ⅡA sulfonate using a 3D circular cyclone-type microreactor被引量：1: 《Chinese Chemical Letters》2024年第1期290-294,共5页Maolin Sun Chaoming Liang Liming Cao Yaguo Wang Jiasheng Yang Shiyu Hou Wei Yu Yueyue Ma Ruihua Cheng Jinxing Ye; the National Natural Science Foundation of China(No.22278087)。; A sustainable and practical process is presented for the direct synthesis of sodium tanshinone IIA sulfonate(STS).Our approach was inspired by the well-established and industrially applied batch synthetic route for ST...; 关键词：Continuous flow Sodium tanshinone IIA sulfonate Cardiovascular MICROREACTOR Green chemistry

Functional characterization of CYP81C16 involved in the tanshinone biosynthetic pathway in Salvia miltiorrhiza被引量：2: 《Chinese Journal of Natural Medicines》2023年第12期938-949,共12页REN Li LUO Linglong HU Zhimin MA Ying WANG Jian CHENG Yatian JIN Baolong CHEN Tong TANG Jinfu CUI Guanghong GUO Juan HUANG Luqi; This work was supported by the National Key R&D Program of China(Nos.2020YFA0908000,2018YFA0900600);the National Natural Science Foundation of China(Nos.82003904,81822046);the Fundamental Research Funds for the Central public welfare research institutes(No.ZZ13-YQ-083);a Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(No.CI2021A04110);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202005);a key project at central government level(the ability to establish sustainable use of valuable Chinese medicine resources;2060302,China).; Danshen,the dried roots and rhizomes of Salvia miltiorrhiza Bunge(S.miltiorrhiza),is widely used in the treatment of cardiovascular and cerebrovascular diseases.Tanshinones,the bioactive compounds from Danshen,exhibit...; 关键词：Salvia miltiorrhiza TANSHINONE Biosynthetic pathway Cytochrome P450 HYDROXYLATION Neocryptotanshinone

Characteristics of Salvia miltiorrhiza methylome and the regulatory mechanism of DNA methylation in tanshinone biosynthesis: 《Horticulture Research》2023年第7期265-279,共15页Jiang Li Caili Li Yuxing Deng Hairong Wei Shanfa Lu; This work was supported by the CAMS Innovation Fund for Medi-cal Sciences(CIFMS)(2021-I2M-2-001).; Salvia miltiorrhiza is a model medicinal plant with significant economic and medicinal value.Its roots produce a group of diterpenoid lipophilic bioactive components,termed tanshinones.Biosynthesis and regulation of t...; 关键词：miltiorrhiza ROOTS MECHANISM

Protective effects of tanshinoneⅡA on sepsis-induced multiple organ dysfunction:a literature review被引量：1: 《Journal of Traditional Chinese Medicine》2023年第5期1040-1046,共7页WANG Lili FENG Ju ZHAN Daqian WANG Junshuai ZHOU Daixing; Natural Science Foundation of Hubei Province:Mechanism of Degenerative Aortic Valve Calcification Induced by Inflammatory Responses in Valvular Interstitial Cells(No.2020CFB577)。; TanshinoneⅡA(TanⅡA)is a noteworthy lipophilic diterpene compound derived from the dried roots of the Traditional Chinese Medicine Danshen(Radix Salviae Miltiorrhizae)that has various pharmacological properties,inclu...; 关键词：tanshinoneⅡA SEPSIS multiple organ failure REVIEW

Preparation of tanshinone Ⅱ_(A) self-soluble microneedles and its inhibition on proliferation of human skin fibroblasts: 《Chinese Herbal Medicines》2023年第2期251-262,共12页Yanshan Zhan Xiaoqi Xu Xi Luo Ruiping Liu Yujian Lin Ping Zhao Jun Shi; supported by the National Natural Science Foundation of China(No.82173982,2021);the Guangdong Natural Science Project(No.2018A0303130234);Excellent Young Teachers Training Project in Higher Education of Guangdong(No.YQ2015099).; Objective:Hypertrophic scars(HS)are a variety of skin tissue fibrosis disease that occurs in human skin,the effective therapeutic method of which is still inaccessible up to now.As a bioactive constituent of a well-kn...; 关键词：human skin fibroblasts hypertrophic scar tanshinoneⅡ_(A) tanshinoneⅡ_(A)self-dissolving microneedles TGF-β1

Efficacy and safety of ACEI plus tanshinone for acute exacerbation of pulmonary heart disease: a meta-analysis: 《Journal of Chinese Pharmaceutical Sciences》2022年第11期853-865,共13页Min Li Lulu Chang Xiangfeng Yue Shuzhang Du; Health Commission of Henan Province (Grant No. LHGJ20190278)。; Acute exacerbation of pulmonary heart disease(AECPHD) is life-threatening. Conventional therapy plus angiotensinconverting enzyme inhibitors(ACEI) is not always practical. Recent trials have suggested the beneficial e...; 关键词：ENALAPRIL CAPTOPRIL TANSHINONE META-ANALYSIS AECPHD

Tanshinone ⅡA prevents acute lung injury by regulating macrophage polarization被引量：6: 《Journal of Integrative Medicine》2022年第3期274-280,共7页Jia-yi Zhao Jin Pu Jian Fan Xin-yu Feng Jian-wen Xu Rong Zhang Yan Shang; supported by National Natural Science Foundation of China (No. 81570020 and 82170033);Natural Science Foundation of Shanghai (21ZR1479200);Shanghai Changhai Hospital Scientific Research Fund (2019SLZ002, 2019YXK018, CHJG2019029 and CHPY2021A05)。; Objective: Acute lung injury(ALI) is a serious respiratory dysfunction caused by pathogen or physical invasion. The strong induced inflammation often causes death. Tanshinone ⅡA(Tan-ⅡA) is the major constituent of S...; 关键词：Acute lung injury INFLAMMATION Cytokine storm TanshinoneⅡA MACROPHAGES

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