Complex Target Volume Delineation and Treatment Planning in Radiotherapy for Malignant Pleural Mesothelioma (MPM)  

Complex Target Volume Delineation and Treatment Planning in Radiotherapy for Malignant Pleural Mesothelioma (MPM)

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作  者:Aaron Innocent Bogmis Adrian Raducu Popa Daniela Adam Violeta Ciocâltei Nicoleta Alina Guraliuc Florin Ciubotaru Ion-Christian Chiricuță Aaron Innocent Bogmis;Adrian Raducu Popa;Daniela Adam;Violeta Ciocâltei;Nicoleta Alina Guraliuc;Florin Ciubotaru;Ion-Christian Chiricuță(Department of Electricity, Solid State Physics & Biophysics, Faculty of Physics, University of Bucharest, Bucharest, Romania;Amethyst Radiotherapy Center, Otopeni, Romania)

机构地区:[1]Department of Electricity, Solid State Physics & Biophysics, Faculty of Physics, University of Bucharest, Bucharest, Romania [2]Amethyst Radiotherapy Center, Otopeni, Romania

出  处:《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》2020年第3期125-140,共16页医学物理学、临床工程、放射肿瘤学(英文)

摘  要:<strong>Introduction:</strong> Radiotherapy alone or combined with surgery and/or chemotherapy is being investigated in the treatment of malignant pleural mesothelioma (MPM). This study aimed to simulate a Volumetric Modulated Arc Therapy (VMAT) treatment of a patient with MPM. <strong>Materials and Methods:</strong> CT images from a patient with intact lungs were imported via DICOM into the Pinnacle3 treatment planning (TP) system (TPS) and used as a model for MPM to delineate organs at risk (OAR) and both clinical and planning target volumes (CTV and PTV) with a margin of 5 mm. Elekta Synergy with 6 MV photons and 80 leafs MLCi2 was employed. VMAT plans were generated using two coplanar arcs with gantry rotation angles of 178<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">&deg</span> - 182<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">&deg</span>, the collimator angles of each arc were set to 90<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">&deg</span>, Octavius<span style="white-space:nowrap;"><sup>&reg;</sup></span> 4D 729 was employed for quality assurance while the calculated and measured doses were compared using VeriSoft. <strong>Results:</strong> A TP was achieved. The Gamma volume analysis with criteria of 3 mm distance to agreement and 3% dose difference yielded the gamma passing rate = 99.9%. The reference isodose was 42.75 Gy with the coverage constraints for the PTV D95 and V95 = 95.0% of 45 Gy. The remaining dosimetric parameters met the recommendations from the clinically acceptable guidelines for the radiotherapy of MPM. <strong>Conclusion:</strong> Using well-defined TV and VMAT, a consistent TP compared to similar ones from publications was achieved. We obtained a high agreement between the 3D dose reconstructed and the dose calculated.<strong>Introduction:</strong> Radiotherapy alone or combined with surgery and/or chemotherapy is being investigated in the treatment of malignant pleural mesothelioma (MPM). This study aimed to simulate a Volumetric Modulated Arc Therapy (VMAT) treatment of a patient with MPM. <strong>Materials and Methods:</strong> CT images from a patient with intact lungs were imported via DICOM into the Pinnacle3 treatment planning (TP) system (TPS) and used as a model for MPM to delineate organs at risk (OAR) and both clinical and planning target volumes (CTV and PTV) with a margin of 5 mm. Elekta Synergy with 6 MV photons and 80 leafs MLCi2 was employed. VMAT plans were generated using two coplanar arcs with gantry rotation angles of 178<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">&deg</span> - 182<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">&deg</span>, the collimator angles of each arc were set to 90<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">&deg</span>, Octavius<span style="white-space:nowrap;"><sup>&reg;</sup></span> 4D 729 was employed for quality assurance while the calculated and measured doses were compared using VeriSoft. <strong>Results:</strong> A TP was achieved. The Gamma volume analysis with criteria of 3 mm distance to agreement and 3% dose difference yielded the gamma passing rate = 99.9%. The reference isodose was 42.75 Gy with the coverage constraints for the PTV D95 and V95 = 95.0% of 45 Gy. The remaining dosimetric parameters met the recommendations from the clinically acceptable guidelines for the radiotherapy of MPM. <strong>Conclusion:</strong> Using well-defined TV and VMAT, a consistent TP compared to similar ones from publications was achieved. We obtained a high agreement between the 3D dose reconstructed and the dose calculated.

关 键 词:Malignant Pleural Mesothelioma Radiation Therapy RADIOTHERAPY Volumetric Modulated Arc Therapy VMAT Target Volume Delineation Treatment Planning CTV PTV 

分 类 号:R73[医药卫生—肿瘤]

 

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