Effect of Dimethoate on Object Recognition Memory in Wistar Rats and Essay of Treatment with Nettle  

作　　者：Majda Samih Pacome Kouadio N’Go Sabah Belaaouja Amina Ouazzani Touhami Ahmed Omar Touhami Ahami 

机构地区：[1]Unit of Clinic and Cognitive Neuroscience,Laboratory of Biology and Health,Department of Biology,Faculty of Sciences,Ibn Tofail University,Kenitra,Morocco [2]Training and Research Unit of Biology Sciences,Peleforo Gon Coulibaly University,Korhogo,Ivory Coast [3]Botanical and Plant Protection Unit,Laboratory of Biology and Health,Department of Biology,Faculty of Sciences,Ibn Tofail University,Kenitra,Morocco

出　　处：《Journal of Behavioral and Brain Science》2017年第9期425-445,共21页行为与脑科学期刊（英文）

摘　　要：Pesticides were economically important chemicals in agriculture. Their use has permitted agricultural progress, through the eradication of harmful insect and the fight against vectors of disease. However, several studies question the beneficial effects of organophosphorus compounds, showing that their deregulated use causes various problems of environmental pollution and human health. The present study shows that chronic exposure to a subtoxic dose of dimethoate is likely to affect cognitive and behavioral functions of rats (both males and females). Our results show that exposure to dimethoate affects both short and long-term memory capacities. The short-term memory results are more pronounced. Treatment with nettle extract allowed a significant improvement in cognitive and behavioral performance of the rats after their exposure to dimethoate.Pesticides were economically important chemicals in agriculture. Their use has permitted agricultural progress, through the eradication of harmful insect and the fight against vectors of disease. However, several studies question the beneficial effects of organophosphorus compounds, showing that their deregulated use causes various problems of environmental pollution and human health. The present study shows that chronic exposure to a subtoxic dose of dimethoate is likely to affect cognitive and behavioral functions of rats (both males and females). Our results show that exposure to dimethoate affects both short and long-term memory capacities. The short-term memory results are more pronounced. Treatment with nettle extract allowed a significant improvement in cognitive and behavioral performance of the rats after their exposure to dimethoate.

关 键 词：DIMETHOATE Dioic Nettle ACETYLCHOLINESTERASE CHELATION MEMORY 

分 类 号：R73[医药卫生—肿瘤]