Effects of Dimethoate Exposure on Locomotor Activity and Anxiety-Like Behavior in Female Wistar Rat  

作　　者：Majda Samih Pacome Kouadio N’Go Sabah Belaaouja Amina Ouazzani Touhami Ahmed Omar Touhami Ahami 

机构地区：[1]Unit of Clinic and Cognitive Neuroscience,Laboratory of Biology and Health,Department of Biology,Faculty of Sciences,IBN TOFAIL University,Kenitra,Morocco [2]Training and Research Unit of Biology Sciences,Peleforo Gon Coulibaly University of Korhogo,Korhogo,Ivory Coast [3]Botanical and Plant Protection Unit,Laboratory of Biology and Health,Department of Biology,Faculty of Sciences,Ibn Tofail University,Kenitra,Morocco

出　　处：《Journal of Behavioral and Brain Science》2017年第10期484-496,共13页行为与脑科学期刊（英文）

摘　　要：Developmental exposure to organophosphate insecticide is well known to induce neurobehavioral impairments, at late period. The present study aims to investigate the effects of subchronic exposure to Dimethoate, on locomotors skills and anxiety like behavior among wistar rat. Two groups of female’s rats are used. The intoxicated group receives daily, during five weeks, by intragastric gavage, a dose of Dimethoate dissolved in corn oil (100 mg/kg body weight). The control group receives only the corn oil. Spontaneous locomotors activity is evaluated using the Open Field test (OF) and anxiety-like behavior is measured using Elevated Plus-Maze (EPM). Dimethoate induced significant impairment of spontaneous locomotors activities, which is reflected by high decrease of number of squares crossed (SC) in OF. Females exposed to Dimethoate develop further anxiety-like response, expressed by significant reductions of the time spent in open arm of Elevated Plus-Maze.Developmental exposure to organophosphate insecticide is well known to induce neurobehavioral impairments, at late period. The present study aims to investigate the effects of subchronic exposure to Dimethoate, on locomotors skills and anxiety like behavior among wistar rat. Two groups of female’s rats are used. The intoxicated group receives daily, during five weeks, by intragastric gavage, a dose of Dimethoate dissolved in corn oil (100 mg/kg body weight). The control group receives only the corn oil. Spontaneous locomotors activity is evaluated using the Open Field test (OF) and anxiety-like behavior is measured using Elevated Plus-Maze (EPM). Dimethoate induced significant impairment of spontaneous locomotors activities, which is reflected by high decrease of number of squares crossed (SC) in OF. Females exposed to Dimethoate develop further anxiety-like response, expressed by significant reductions of the time spent in open arm of Elevated Plus-Maze.

关 键 词：Acetylcholinesterase Activity NEUROTOXICITY DIMETHOATE NEUROBEHAVIOR Organophosphate Insecticides 

分 类 号：R73[医药卫生—肿瘤]