Analysis of the Effects of Botulinum Toxin Type A to Promote the Survival of Transverse Rectus Abdominis Myocutaneous Flaps in an Animal Model  

作　　者：Erika Otilia Haro García Edna M. Aizpuru Jorge Eduardo Gutierrez Salgado Maria Irene Rivera Salgado Jose Telich Vidal Olin Carrasco Ortiz Erika Otilia Haro García;Edna M. Aizpuru;Jorge Eduardo Gutierrez Salgado;Maria Irene Rivera Salgado;Jose Telich Vidal;Olin Carrasco Ortiz(Department of Plastic and Reconstructive Surgery at Hospital Angeles del Pedregal, Mexico City, Mexico;Department of Plastic and Reconstructive Surgery at PEMEX Hospital, Facultad Mexicana de Medicina, Universidad la Salle, Mexico City, Mexico;Facultad Medicina UNAM, Mexico City, Mexico;Department of Pathology in Pemex Hospital, Mexico City, Mexico;Facultad Mexicana de Medicina, Universidad la Salle, Mexico City, Mexico)

机构地区：[1]Department of Plastic and Reconstructive Surgery at Hospital Angeles del Pedregal, Mexico City, Mexico [2]Department of Plastic and Reconstructive Surgery at PEMEX Hospital, Facultad Mexicana de Medicina, Universidad la Salle, Mexico City, Mexico [3]Facultad Medicina UNAM, Mexico City, Mexico [4]Department of Pathology in Pemex Hospital, Mexico City, Mexico [5]Facultad Mexicana de Medicina, Universidad la Salle, Mexico City, Mexico

出　　处：《Journal of Biosciences and Medicines》2020年第10期63-73,共11页生物科学与医学（英文）

摘　　要：The transverse rectus abdominis myocutaneous (TRAM) flap is one of the techniques for breast reconstruction surgery and other defects. Assuring the vascular input is the main factor that it should be ensured for the survival of the fap. <strong>Objective:</strong> The article presented is an experimental study, with the objective of evaluating the effect of the vasculature on the myocutaneous flaps of the abdominal rectum with botulinum toxin type A (TBoA) thay may improve the survival of the tissue by promoting the blood perfusion in distal parts of the flap and diminish the risk of necrosis. <strong>Material and methods:</strong> A total of 30 Wistar male rats, dissect pedicled right TRAM flap in all rats, divided into three groups: Group 1 was applied in saline solution 0.9%;Group 2 was applied in pre surgically TBoA (1 week before lifting the flap);Group 3, will apply TBOA Trans surgical. <strong>Results:</strong> Histological analysis showed: increased vascularity in group 2 TBoA compared with the saline solution with P < 0.05 statistically significant. In terms of fibrosis, inflammation and granulation tissue, there was no statistically significant difference at p = 0.6. Muscle atrophy was higher in the group of TBoA in the saline group p < 0.05. It was concluded that botulinum toxin type A prevents vasoconstriction of the vessel and promotes vasodilation subsequently lifting the muscle flap, no complications were observed in the groups with TBoA so it can be considered a safe substace and can be used for further studies.The transverse rectus abdominis myocutaneous (TRAM) flap is one of the techniques for breast reconstruction surgery and other defects. Assuring the vascular input is the main factor that it should be ensured for the survival of the fap. <strong>Objective:</strong> The article presented is an experimental study, with the objective of evaluating the effect of the vasculature on the myocutaneous flaps of the abdominal rectum with botulinum toxin type A (TBoA) thay may improve the survival of the tissue by promoting the blood perfusion in distal parts of the flap and diminish the risk of necrosis. <strong>Material and methods:</strong> A total of 30 Wistar male rats, dissect pedicled right TRAM flap in all rats, divided into three groups: Group 1 was applied in saline solution 0.9%;Group 2 was applied in pre surgically TBoA (1 week before lifting the flap);Group 3, will apply TBOA Trans surgical. <strong>Results:</strong> Histological analysis showed: increased vascularity in group 2 TBoA compared with the saline solution with P < 0.05 statistically significant. In terms of fibrosis, inflammation and granulation tissue, there was no statistically significant difference at p = 0.6. Muscle atrophy was higher in the group of TBoA in the saline group p < 0.05. It was concluded that botulinum toxin type A prevents vasoconstriction of the vessel and promotes vasodilation subsequently lifting the muscle flap, no complications were observed in the groups with TBoA so it can be considered a safe substace and can be used for further studies.

关 键 词：Botulinum Toxin Tranverse Rectus Abdominis Myocutaneos Flap VASODILATATION SURVIVAL 

分 类 号：R73[医药卫生—肿瘤]