Exploration of Related Issues on PK/PD Studies and Bioanalytical Characteristics of Peptides  

作　　者：Chiyu He Yuxi Hu Chiyu He;Yuxi Hu(Center for Drug Evaluation, National Medical Products Administration, Beijing, China)

机构地区：[1]Center for Drug Evaluation, National Medical Products Administration, Beijing, China

出　　处：《Journal of Biosciences and Medicines》2023年第11期76-93,共18页生物科学与医学（英文）

摘　　要：Peptides play multiple functions in cellular processes and are considered an attractive paradigm for the development of novel drugs and therapeutic approaches. However, the complexity of their pharmacokinetics/pharmacodynamics and physicochemical properties presents challenges in their development. Currently, there is no single analytical method that fully meets the requirements for studying peptide drug pharmacokinetics. Interdisciplinary teams and multiple technical platforms are required to address these challenges. This article explores the pharmacokinetics, bioanalytical methods, challenges, and strategies in the development of peptide drugs. As our understanding of peptide drug pharmacokinetics and bioanalytical characteristics deepens, it will facilitate their development and provide scientific evidence for rational clinical use.Peptides play multiple functions in cellular processes and are considered an attractive paradigm for the development of novel drugs and therapeutic approaches. However, the complexity of their pharmacokinetics/pharmacodynamics and physicochemical properties presents challenges in their development. Currently, there is no single analytical method that fully meets the requirements for studying peptide drug pharmacokinetics. Interdisciplinary teams and multiple technical platforms are required to address these challenges. This article explores the pharmacokinetics, bioanalytical methods, challenges, and strategies in the development of peptide drugs. As our understanding of peptide drug pharmacokinetics and bioanalytical characteristics deepens, it will facilitate their development and provide scientific evidence for rational clinical use.

关 键 词：PEPTIDES DRUGS PK/PD Bioanalytical Characteristics 

分 类 号：O62[理学—有机化学]