Brain Urea as a Potential Biomarker of Neoplasm Progression  

作　　者：Larisa Mikhailovna Obukhova Elena Ivanovna Erlykina Igor Aleksandrovich Medyanik Artem Sergeevich Grishin Angelina Mikhailovna Shutova Larisa Mikhailovna Obukhova;Elena Ivanovna Erlykina;Igor Aleksandrovich Medyanik;Artem Sergeevich Grishin;Angelina Mikhailovna Shutova(Federal State Budgetary Educational Institution of Higher Education, The “,Privolzhsky Research Medical University”, of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia;National Research Lobachevsky State, University of Nizhny Novgorod, Nizhny Novgorod, Russia)

机构地区：[1]Federal State Budgetary Educational Institution of Higher Education, The “,Privolzhsky Research Medical University”, of the Ministry of Health of the Russian Federation, Nizhny Novgorod, Russia [2]National Research Lobachevsky State, University of Nizhny Novgorod, Nizhny Novgorod, Russia

出　　处：《Journal of Biosciences and Medicines》2024年第4期1-13,共13页生物科学与医学（英文）

摘　　要：Metabolic reprogramming is a key feature driving oncogenesis in cancers. Recent studies have revealed that protein metabolism is largely altered in gliomas facilitating its malignant growth. Urea is the end product of nitrogen metabolism which is mainly produced by arginase. The interdependence of arginase and other biochemical mechanisms triggered scientific research interest. This research aimed to investigate the relationships between the urea as the main parameter of protein metabolism and glioma progression. It was also the most pronounced relationship between urea and the level of the nuclear protein Ki-67 as a marker of proliferative activity and O-6-methylguanine-DNA methyltransferase (MGMT), which performs DNA repair. Postoperative material from 20 patients with gliomas of different grades of anaplasia was analyzed.Metabolic reprogramming is a key feature driving oncogenesis in cancers. Recent studies have revealed that protein metabolism is largely altered in gliomas facilitating its malignant growth. Urea is the end product of nitrogen metabolism which is mainly produced by arginase. The interdependence of arginase and other biochemical mechanisms triggered scientific research interest. This research aimed to investigate the relationships between the urea as the main parameter of protein metabolism and glioma progression. It was also the most pronounced relationship between urea and the level of the nuclear protein Ki-67 as a marker of proliferative activity and O-6-methylguanine-DNA methyltransferase (MGMT), which performs DNA repair. Postoperative material from 20 patients with gliomas of different grades of anaplasia was analyzed.

关 键 词：GLIOMA Peritumoral Zone UREA Gliomal Molecular Genetic Markers Ki-67 MGMT 

分 类 号：R73[医药卫生—肿瘤]