Advancements in the Research of Gold Nanomaterials for Radiation Therapy Sensitization  

作　　者：Yuzhe Zhang Xiaohui Zhao Xin He Shengni Hua Yusheng Shi Yuzhe Zhang;Xiaohui Zhao;Xin He;Shengni Hua;Yusheng Shi(Department of Radiation Oncology, Zhuhai Peoples Hospital, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China)

机构地区：[1]Department of Radiation Oncology, Zhuhai Peoples Hospital, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China

出　　处：《Journal of Biosciences and Medicines》2024年第11期538-555,共18页生物科学与医学（英文）

摘　　要：Gold nanomaterials exhibit unique advantages in tumor radiotherapy sensitization due to their enhanced X-ray deposition capability, excellent biocompatibility, and superior chemical, electronic, and optical properties. To date, studies on gold nanomaterial-mediated radiosensitization have been reported, with related mechanisms including catalyzing reactive oxygen species (ROS) production, depleting intracellular glutathione (GSH), overcoming tumor hypoxia, and regulating cell cycles. This article will elaborate on the research progress of gold nanomaterial-mediated tumor radiotherapy sensitization and discuss its mechanisms and future research directions. In addition, the limitations of gold nanomaterials in clinical applications will be further discussed.Gold nanomaterials exhibit unique advantages in tumor radiotherapy sensitization due to their enhanced X-ray deposition capability, excellent biocompatibility, and superior chemical, electronic, and optical properties. To date, studies on gold nanomaterial-mediated radiosensitization have been reported, with related mechanisms including catalyzing reactive oxygen species (ROS) production, depleting intracellular glutathione (GSH), overcoming tumor hypoxia, and regulating cell cycles. This article will elaborate on the research progress of gold nanomaterial-mediated tumor radiotherapy sensitization and discuss its mechanisms and future research directions. In addition, the limitations of gold nanomaterials in clinical applications will be further discussed.

关 键 词：Gold Nanomaterials RADIOTHERAPY SENSITIZATION 

分 类 号：R73[医药卫生—肿瘤]