Effect of Aqueous Extract of Boscia senegalensis on Hyperglycemia, Hyperlipidemia and Oxidative Stress Induced in Rats  

作　　者：Faustin Dongmo Elie Baudelaire Djantou Alcherif Hamid Mahamat Selestin Sokeng Dongmo Nicolas Njintang Yanou Faustin Dongmo;Elie Baudelaire Djantou;Alcherif Hamid Mahamat;Selestin Sokeng Dongmo;Nicolas Njintang Yanou(Department of Biological Sciences, Faculty of Science, University of Ngaoundere, Ngaoundere, Cameroon;Department of Food Science and Nutrition, ENSAI, University of Ngaoundere, Ngaoundere, Cameroon;Department of Biomedical and Pharmacetical Sciences, National Higher Institute of Science and Techniques of Abeche, Abeche, Chad)

机构地区：[1]Department of Biological Sciences, Faculty of Science, University of Ngaoundere, Ngaoundere, Cameroon [2]Department of Food Science and Nutrition, ENSAI, University of Ngaoundere, Ngaoundere, Cameroon [3]Department of Biomedical and Pharmacetical Sciences, National Higher Institute of Science and Techniques of Abeche, Abeche, Chad

出　　处：《Journal of Diabetes Mellitus》2024年第1期49-68,共20页糖尿病（英文）

摘　　要：Boscia aqueous extract. senegalensis on hyperglycemia, hyperlipidemia and oxidative stress induced in rats. The aqueous extract was prepared from B. senegalensis seed powders under the extraction conditions: time (10 min), temperature (55˚C) and the ratio of mass of flour/volume of water (3/10 g/mL). Male wistar rats aged 6 to 8 weeks were acclimated and divided into 8 groups of 5 rats each: two normal control groups which received a normal standard diet (3810 kcal/kg), and six test groups which were subjected to a hyperlipidemic diet (5310 Kcal/kg). All groups of animals were fed in this manner for 8 weeks to induce hyperglycemia, hyperlipidemia and oxidative stress. After induction the animals were treated either with distilled water for the normal and negative control groups or with atorvastatin for the positive control group or with the extract of B. senegalensis. (125, 250 and 500 mg/kg) for the test groups. Fasting blood glucose was taken every 7 days during induction. After sacrifice, biochemical and oxidative stress parameters were measured. The aqueous extract of B. senegalensis significantly decreased (p B. senegalensis at a dose of 500 mg/kg has the capacity to reduce blood sugar, improve the quality of the lipid profile and reduce oxidative stress. Thus, the results reveal that the aqueous extract of B. senegalensis has powerful hypoglycemic, hypolipidemic and antioxidant properties.Boscia aqueous extract. senegalensis on hyperglycemia, hyperlipidemia and oxidative stress induced in rats. The aqueous extract was prepared from B. senegalensis seed powders under the extraction conditions: time (10 min), temperature (55˚C) and the ratio of mass of flour/volume of water (3/10 g/mL). Male wistar rats aged 6 to 8 weeks were acclimated and divided into 8 groups of 5 rats each: two normal control groups which received a normal standard diet (3810 kcal/kg), and six test groups which were subjected to a hyperlipidemic diet (5310 Kcal/kg). All groups of animals were fed in this manner for 8 weeks to induce hyperglycemia, hyperlipidemia and oxidative stress. After induction the animals were treated either with distilled water for the normal and negative control groups or with atorvastatin for the positive control group or with the extract of B. senegalensis. (125, 250 and 500 mg/kg) for the test groups. Fasting blood glucose was taken every 7 days during induction. After sacrifice, biochemical and oxidative stress parameters were measured. The aqueous extract of B. senegalensis significantly decreased (p B. senegalensis at a dose of 500 mg/kg has the capacity to reduce blood sugar, improve the quality of the lipid profile and reduce oxidative stress. Thus, the results reveal that the aqueous extract of B. senegalensis has powerful hypoglycemic, hypolipidemic and antioxidant properties.

关 键 词：Boscia Senegalensis HYPOGLYCEMIC HYPOLIPIDEMIC Hyperlipidemic Diet An-tioxidant 

分 类 号：R28[医药卫生—中药学]