A Study on Pulmonary Tuberculosis and Risk Factors in New and Re-Treated Presumptive Patients at Wad Madani Tuberculosis Center, Sudan (2018-2019): A Cross-Sectional Study  

作　　者：Zeinab H. Alfaham Elhadi A. Ahmed Elamin M. Ibrahim Mohamed Soud Mohamed Ameer A. Mohamed Ayman Mahjob Mubarak A. Elshafia Bakri Y. M. Nour Zeinab H. Alfaham;Elhadi A. Ahmed;Elamin M. Ibrahim;Mohamed Soud Mohamed;Ameer A. Mohamed;Ayman Mahjob;Mubarak A. Elshafia;Bakri Y. M. Nour(Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan;Department of Microbiology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan;Department of Surgery, Faculty of Medicine, University of Gezira, Wad Medani, Sudan;Department of Medicine, Wad Medani Teaching Hospital, Gezira State Ministry of Health, Wad Medani, Sudan;Wad Madani Tuberculosis Center, Gezira State Ministry of Health, Wad Medani, Sudan;Department of Haematology and Immunohaematology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan;Department of Medical Parasitology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan)

机构地区：[1]Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan [2]Department of Microbiology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan [3]Department of Surgery, Faculty of Medicine, University of Gezira, Wad Medani, Sudan [4]Department of Medicine, Wad Medani Teaching Hospital, Gezira State Ministry of Health, Wad Medani, Sudan [5]Wad Madani Tuberculosis Center, Gezira State Ministry of Health, Wad Medani, Sudan [6]Department of Haematology and Immunohaematology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan [7]Department of Medical Parasitology, Faculty of Medical Laboratory Sciences, University of Gezira, Wad Medani, Sudan

出　　处：《Journal of Tuberculosis Research》2022年第1期18-27,共10页结核病研究（英文）

摘　　要：Introduction: The increase in cases of drug-resistant pulmonary tuberculosis, especially in endemic areas, is mainly associated with re-treatment, although resistant tubercle bacilli can be easily transmitted between all susceptible persons. Objective: The study aimed to describe pulmonary tuberculosis, risk factors and MDR in new and re-treated suspected patients attending Wad Madani Tuberculosis Center that provides service in central Sudan. Methods: Cross-sectional laboratory based study among 300 presumptive pulmonary tuberculosis patients during 2018 and 2019 was conducted. Cases were divided into new and re-treated. Mycobacterium tuberculosis DNA and rpoB gene of multi-drug resistance (MDR) were detected in sputum samples by GeneXpert assay as manufacturer instructions. Results: Out of 300 suspected participants, 34% (103/300) were diagnosed as pulmonary tuberculosis using GeneXpert method. The frequency of males, the age group from 21 to 40 and rural housing were the most with percentage reach 68% (70/103), 51% (53/103) and 58.3% (60/103) respectively. All observed symptoms were significantly associated with pulmonary tuberculosis. New cases represented 59.2% (61/103) while re-treated was 40.8% (39/103). The overall frequency of MDR patients was 9.7% (10/103) of which 50% (5/103) had relapse situation. Conclusion: It appeared that the cases of MDR pulmonary tuberculosis are on the increase compared to previous findings, recommended measures must be taken to control the spread of tuberculosis and the causes of re-treatment and relapse must be studied.Introduction: The increase in cases of drug-resistant pulmonary tuberculosis, especially in endemic areas, is mainly associated with re-treatment, although resistant tubercle bacilli can be easily transmitted between all susceptible persons. Objective: The study aimed to describe pulmonary tuberculosis, risk factors and MDR in new and re-treated suspected patients attending Wad Madani Tuberculosis Center that provides service in central Sudan. Methods: Cross-sectional laboratory based study among 300 presumptive pulmonary tuberculosis patients during 2018 and 2019 was conducted. Cases were divided into new and re-treated. Mycobacterium tuberculosis DNA and rpoB gene of multi-drug resistance (MDR) were detected in sputum samples by GeneXpert assay as manufacturer instructions. Results: Out of 300 suspected participants, 34% (103/300) were diagnosed as pulmonary tuberculosis using GeneXpert method. The frequency of males, the age group from 21 to 40 and rural housing were the most with percentage reach 68% (70/103), 51% (53/103) and 58.3% (60/103) respectively. All observed symptoms were significantly associated with pulmonary tuberculosis. New cases represented 59.2% (61/103) while re-treated was 40.8% (39/103). The overall frequency of MDR patients was 9.7% (10/103) of which 50% (5/103) had relapse situation. Conclusion: It appeared that the cases of MDR pulmonary tuberculosis are on the increase compared to previous findings, recommended measures must be taken to control the spread of tuberculosis and the causes of re-treatment and relapse must be studied.

关 键 词：MDR Pulmonary Tuberculosis RELAPSE SUDAN 

分 类 号：R52[医药卫生—内科学]