Antiulcer Activities of Commiphora molmol (Myrrh) Extract in Male Rats  

作　　者：Nehal A. A. Alfky Reham A. Mustafa Eslam A. Header Naser A. El Sawy Abdullah G. Al-Kushi Nehal A. A. Alfky;Reham A. Mustafa;Eslam A. Header;Naser A. El Sawy;Abdullah G. Al-Kushi(Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al Qura University, Mecca, KSA;Department of Nutrition and Food Science, Faculty of Home Economics, Minufiya University, Monufia Governorate, Egypt;Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al Qura University, Mecca, KSA;Department of Anatomy and Embryology, Faculty of Medicine, Zagazig University, Ismailia, Egypt;Department of Anatomy, Faculty of Medicine, Umm Al Qura University, Mecca, KSA)

机构地区：[1]Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al Qura University, Mecca, KSA [2]Department of Nutrition and Food Science, Faculty of Home Economics, Minufiya University, Monufia Governorate, Egypt [3]Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al Qura University, Mecca, KSA [4]Department of Anatomy and Embryology, Faculty of Medicine, Zagazig University, Ismailia, Egypt [5]Department of Anatomy, Faculty of Medicine, Umm Al Qura University, Mecca, KSA

出　　处：《Open Journal of Gastroenterology》2016年第10期300-309,共10页肠胃病学期刊（英文）

摘　　要：Medicinal plants used in folk medicine contain a wide range of substances that can prevent and treat many diseases. The Antiulcer Activities effects of myrrh or Commiphora molmol extract (CME) were assessed in rats. In this experiment, thirty rats were divided into 6 groups as follows: G1) normal control (vehicle);G2) received aspirin without any treatment;G3) pretreated with Omeprazole (antiulcer drug) and groups (4), (5) and (6) were pretreated with CME at 125, 250 and 500 mg/kg b.wt, respective-ly for 2 weeks. At the end of experiment the volume, pH and total acidity of gastric juices;mucus content and ulcer lengths were measured and protection percentages were calculated. Gross and histopathological examinations of stomachs were also performed. CME induced an antiulcer effect manifested by decreased volume and total acidity of gastric juice and increased mucus content and percentages of protec-tion from ulcer as well as partial amelioration of gross and histopathological lesions seen in stomach of ulcerated rats. In conclusion, the results denote that Commiphora molmol extract possess antiulcer effects in rats. These results affirm the traditional use of Myrrh extract for the treatment of gastric ulcer.Medicinal plants used in folk medicine contain a wide range of substances that can prevent and treat many diseases. The Antiulcer Activities effects of myrrh or Commiphora molmol extract (CME) were assessed in rats. In this experiment, thirty rats were divided into 6 groups as follows: G1) normal control (vehicle);G2) received aspirin without any treatment;G3) pretreated with Omeprazole (antiulcer drug) and groups (4), (5) and (6) were pretreated with CME at 125, 250 and 500 mg/kg b.wt, respective-ly for 2 weeks. At the end of experiment the volume, pH and total acidity of gastric juices;mucus content and ulcer lengths were measured and protection percentages were calculated. Gross and histopathological examinations of stomachs were also performed. CME induced an antiulcer effect manifested by decreased volume and total acidity of gastric juice and increased mucus content and percentages of protec-tion from ulcer as well as partial amelioration of gross and histopathological lesions seen in stomach of ulcerated rats. In conclusion, the results denote that Commiphora molmol extract possess antiulcer effects in rats. These results affirm the traditional use of Myrrh extract for the treatment of gastric ulcer.

关 键 词：Commiphora molmol Myrrh Extract ANTIULCER Gastric Juices OMEPRAZOLE 

分 类 号：R57[医药卫生—消化系统]