Updated Review on the Panorama of Liver Diseases in Benin  

作　　者：Jean Sehonou Aboudou Raïmi Kpossou Celia Rosemonde Ablavi Mouzouvi Comlan N’déhougbèa Martin Sokpon Rodolph Koffi Vignon Jean Sehonou;Aboudou Raïmi Kpossou;Celia Rosemonde Ablavi Mouzouvi;Comlan N’déhougbèa Martin Sokpon;Rodolph Koffi Vignon(Hepato-Gastroenterology Department, National and University Hospital Hubert Koutoukou Maga (CNHU-HKM), Cotonou, Benin Republic;Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin Republic;Galenic Pharmacy and Pharmaceutical Technology Laboratory, Pharmacy Teaching and Research Unit, Faculty of Health Sciences, Cotonou, Benin Republic)

机构地区：[1]Hepato-Gastroenterology Department, National and University Hospital Hubert Koutoukou Maga (CNHU-HKM), Cotonou, Benin Republic [2]Faculty of Health Sciences, University of Abomey-Calavi, Cotonou, Benin Republic [3]Galenic Pharmacy and Pharmaceutical Technology Laboratory, Pharmacy Teaching and Research Unit, Faculty of Health Sciences, Cotonou, Benin Republic

出　　处：《Open Journal of Gastroenterology》2023年第1期33-42,共10页肠胃病学期刊（英文）

摘　　要：Introduction: The aim of this work was to take stock of the epidemiological aspects of liver diseases in Benin. Methods: Two methods were used: documentary research and collection of the position of gastroenterologists on the subject. For the literature search, the sources interviewed were Medline, African Journal On Line (AJOL), Google and Google scholar. Additional searches were made on the websites of European gastroenterology societies (AFEF, EASL). A collection of the opinions of gastroenterologists, most of them members of the Beninese Society of Hepato-gastroenterology was made. Results: From a nosological point of view, the most frequent and serious liver diseases in Benin are mainly infectious: viral hepatitis B and C (9.9% and 4.12% of the general population in 2013). Bacterial liver diseases (ascites fluid infections and tuberculosis of the liver) come in 3rd position after cirrhosis and hepatocellular carcinoma. Amoebic abscesses of the liver tend to regress. The toxic causes are dominated, in addition to alcoholic liver diseases (steatosis, cirrhosis), by drug lesions: two fatal cases of hepatotoxicity by artesunate-amodiaquine combination and asymptomatic and transient cytolysis in 23.8% of 63 children less than 5 years old treated with arthemether-lumefantrine combination have been described. Phytotherapy, alone or in combination with modern drugs, can in some cases be hepatotoxic. Plants with recognized medicinal virtues (may be harmful to the liver (Senna, Moringa oleifera, tamarind). Chronic aflatoxicoses secondary to the consumption of contaminated food (maize, cassava or peanuts) are relatively under-documented. Overload diseases (in particular alcoholic or non-alcoholic fatty liver) are on the increase (3.19% of 662 ultrasounds in 1995 against 14.5% of 411 in 2011 in Cotonou) partly due to the demographic and nutritional transition underway in Benin. These diseases, often blamed on spells cast, lead to hospital deaths from cirrhosis or hepatocellular carcinoma in young economically active subIntroduction: The aim of this work was to take stock of the epidemiological aspects of liver diseases in Benin. Methods: Two methods were used: documentary research and collection of the position of gastroenterologists on the subject. For the literature search, the sources interviewed were Medline, African Journal On Line (AJOL), Google and Google scholar. Additional searches were made on the websites of European gastroenterology societies (AFEF, EASL). A collection of the opinions of gastroenterologists, most of them members of the Beninese Society of Hepato-gastroenterology was made. Results: From a nosological point of view, the most frequent and serious liver diseases in Benin are mainly infectious: viral hepatitis B and C (9.9% and 4.12% of the general population in 2013). Bacterial liver diseases (ascites fluid infections and tuberculosis of the liver) come in 3rd position after cirrhosis and hepatocellular carcinoma. Amoebic abscesses of the liver tend to regress. The toxic causes are dominated, in addition to alcoholic liver diseases (steatosis, cirrhosis), by drug lesions: two fatal cases of hepatotoxicity by artesunate-amodiaquine combination and asymptomatic and transient cytolysis in 23.8% of 63 children less than 5 years old treated with arthemether-lumefantrine combination have been described. Phytotherapy, alone or in combination with modern drugs, can in some cases be hepatotoxic. Plants with recognized medicinal virtues (may be harmful to the liver (Senna, Moringa oleifera, tamarind). Chronic aflatoxicoses secondary to the consumption of contaminated food (maize, cassava or peanuts) are relatively under-documented. Overload diseases (in particular alcoholic or non-alcoholic fatty liver) are on the increase (3.19% of 662 ultrasounds in 1995 against 14.5% of 411 in 2011 in Cotonou) partly due to the demographic and nutritional transition underway in Benin. These diseases, often blamed on spells cast, lead to hospital deaths from cirrhosis or hepatocellular carcinoma in young economically active sub

关 键 词：Viral Hepatitis Drug-Induced Hepatitis BENIN Viral Hepatitis Toxic Hepatitis 

分 类 号：R57[医药卫生—消化系统]