Hepatic Elastometry in the Management of Hepatitis B at National Hospital of Niamey  

作　　者：Ousseini Fanta Hamidine Illa Moussa Saley Sahada Abdourahamane Idrissa Fatouma Abdou Nafissatou Ali Cheik Rakia Abdou Boubé Abdou Djibo Ben Moctar Ky Lawagoulé Joseph Emile Daou Mamane Ousseini Fanta;Hamidine Illa;Moussa Saley Sahada;Abdourahamane Idrissa Fatouma;Abdou Nafissatou;Ali Cheik Rakia;Abdou Boubé;Abdou Djibo Ben Moctar;Ky Lawagoulé Joseph Emile;Daou Mamane(Faculty of Health Sciences, Abdou Moumouni University, Niamey, Niger;Department of Hepato-Gastroenterology, National Hospital of Niamey, Niamey, Niger;Laboratoire de Recherche Clinique et Systme de Sant Niger, Universit Andr Salifou of Zinder, Zinder, Niger;Department of Hepato-Gastroenterology, Zinder National Hospital, Zinder, Niger;Department of Infectiology, National Hospital of Niamey, Niamey, Niger;Regional Hospital Centre of Niamey, Niamey, Niger;Department of Hepato-Gastroenterology, General Reference Hospital of Niamey, Niamey, Niger;Department of Hepato-Gastroenterology, The University Hospital, Ouagadougou, Burkina Faso;Department of Internal Medicine, General Reference Hospital of Niamey, Niamey, Niger)

机构地区：[1]Faculty of Health Sciences, Abdou Moumouni University, Niamey, Niger [2]Department of Hepato-Gastroenterology, National Hospital of Niamey, Niamey, Niger [3]Laboratoire de Recherche Clinique et Systme de Sant Niger, Universit Andr Salifou of Zinder, Zinder, Niger [4]Department of Hepato-Gastroenterology, Zinder National Hospital, Zinder, Niger [5]Department of Infectiology, National Hospital of Niamey, Niamey, Niger [6]Regional Hospital Centre of Niamey, Niamey, Niger [7]Department of Hepato-Gastroenterology, General Reference Hospital of Niamey, Niamey, Niger [8]Department of Hepato-Gastroenterology, The University Hospital, Ouagadougou, Burkina Faso [9]Department of Internal Medicine, General Reference Hospital of Niamey, Niamey, Niger

出　　处：《Open Journal of Gastroenterology》2024年第9期313-321,共9页肠胃病学期刊（英文）

摘　　要：Introduction: Viral hepatitis B is a public health problem in Niger which is classified as a high endemicity area with a prevalence ranging from 8 to 17% depending on the studies [1] and that of HBV-related cirrhosis is about 40.26% in 2024. The decision to treat is based on a combination of three parameters: viral load, ALT values and the degree of hepatic fibrosis [2]. The latter is assessed by hepatic elastography (Fibroscan), which is a decisive factor in treatment. In Niger, until 2024, the decision to treat or not to treat a patient with HBV was based on the determination of viral load B and transaminases, and no work evaluating the contribution of this third element, liver elasticity, has been done, hence the interest of our study. Objective: To study the contribution of Fibroscan in measuring hepatic elasticity in the management of patients with HBV. Methodology: This was a prospective descriptive study conducted from January 05 to November 30, i.e. a period of 11 months, on clinically asymptomatic HBsAg-positive patients who had undergone FibroScan liver elasticity measurement. The examination was carried out by a hepatogastroenterologist who had received training in the Fibroscan. The median of ten measures of liver elasticity at the same point with an IQR of less than 30% was considered the valid measure and no or minimal fibrosis was defined as a value ˂7 Kpa, moderate fibrosis as a value between 7 and 10 kpa, severe fibrosis as a value greater than 10 Kpa, and the existence of cirrhosis as a value greater than 14 Kpa were analyzed using SPSS version 20 software. Results: Out of 398 patients monitored for HBV, 60 cases met the inclusion criteria, i.e., a frequency of 15.07%. The mean age of the patients was 35.63 years, with extremes of 18 and 70 years. They were predominantly male, with a sex ratio of 3.2. Married patients accounted for 61.67% (n = 37). Jaundice was absent in 91.67% (n = 55). The circumstances of discovery of HBV were the routine health check-up, followed by blood donation with 50% Introduction: Viral hepatitis B is a public health problem in Niger which is classified as a high endemicity area with a prevalence ranging from 8 to 17% depending on the studies [1] and that of HBV-related cirrhosis is about 40.26% in 2024. The decision to treat is based on a combination of three parameters: viral load, ALT values and the degree of hepatic fibrosis [2]. The latter is assessed by hepatic elastography (Fibroscan), which is a decisive factor in treatment. In Niger, until 2024, the decision to treat or not to treat a patient with HBV was based on the determination of viral load B and transaminases, and no work evaluating the contribution of this third element, liver elasticity, has been done, hence the interest of our study. Objective: To study the contribution of Fibroscan in measuring hepatic elasticity in the management of patients with HBV. Methodology: This was a prospective descriptive study conducted from January 05 to November 30, i.e. a period of 11 months, on clinically asymptomatic HBsAg-positive patients who had undergone FibroScan liver elasticity measurement. The examination was carried out by a hepatogastroenterologist who had received training in the Fibroscan. The median of ten measures of liver elasticity at the same point with an IQR of less than 30% was considered the valid measure and no or minimal fibrosis was defined as a value ˂7 Kpa, moderate fibrosis as a value between 7 and 10 kpa, severe fibrosis as a value greater than 10 Kpa, and the existence of cirrhosis as a value greater than 14 Kpa were analyzed using SPSS version 20 software. Results: Out of 398 patients monitored for HBV, 60 cases met the inclusion criteria, i.e., a frequency of 15.07%. The mean age of the patients was 35.63 years, with extremes of 18 and 70 years. They were predominantly male, with a sex ratio of 3.2. Married patients accounted for 61.67% (n = 37). Jaundice was absent in 91.67% (n = 55). The circumstances of discovery of HBV were the routine health check-up, followed by blood donation with 50%

关 键 词：Hepatic Elasticity FIBROSCAN FIBROSIS Hepatitis B NIGER 

分 类 号：R57[医药卫生—消化系统]