Demographic and Clinical Characteristics of 63 Children with Myelomeningoceles  

作　　者：Youssouf Sogoba Seybou Hassane Diallo Issa Amadou Boubacar Sogoba Moussa Diallo Benoi Kamaté Daouda Mariko Coulibaly Oumar Quenum Kisito Hawa Diall Leonie Diakité Salimata Diallo Belco Maiga Fousseyni Traoré Karamoko Sacko Oumar Diallo Drissa Kanikomo Youssoufa Maiga Youssouf Sogoba;Seybou Hassane Diallo;Issa Amadou;Boubacar Sogoba;Moussa Diallo;Benoi Kamaté;Daouda Mariko;Coulibaly Oumar;Quenum Kisito;Hawa Diall;Leonie Diakité;Salimata Diallo;Belco Maiga;Fousseyni Traoré;Karamoko Sacko;Oumar Diallo;Drissa Kanikomo;Youssoufa Maiga(Department of Neurosurgery, Hôpital Gabriel Touré, Bamako, Mali;Department of Neurology, Hôpital Gabriel Touré, Bamako, Mali;Department of Pediatric Surgery, Hôpital Gabriel Touré, Bamako, Mali;Department of Neurosurgery, Hôpital du Mali, Bamako, Mali;Department of Neurosurgery, University Hospital of Parakou, Parakou, Benin;Department of Pediatrics, Hôpital Gabriel Touré, Bamako, Mali)

机构地区：[1]Department of Neurosurgery, Hô pital Gabriel Touré, Bamako, Mali [2]Department of Neurology, Hô pital Gabriel Touré, Bamako, Mali [3]Department of Pediatric Surgery, Hô pital Gabriel Touré, Bamako, Mali [4]Department of Neurosurgery, Hô pital du Mali, Bamako, Mali [5]Department of Neurosurgery, University Hospital of Parakou, Parakou, Benin [6]Department of Pediatrics, Hô pital Gabriel Touré, Bamako, Mali

出　　处：《Open Journal of Modern Neurosurgery》2021年第2期59-64,共6页现代神经外科学进展（英文）

摘　　要：<strong>Background:</strong> Myelomeningocele (MMC) is the most common neural tube defect (NTD) characterized by the extrusion of the spinal cord into a sac filled with cerebrospinal fluid, resulting in lifelong disability. In the general population, the incidence of MMC ranges from 0.3 to 4.5/10,000 births. Live born infants with myelomeningocele have a death rate of approximately 10%. Many factors may play a role in the development of MMC such as environmental and genetic factors. In this study, we present our experience with a group of 63 children afflicted with MMC. <strong>Methods:</strong> This study was a retrospective analysis of 63 patients with MMC admitted to the neurosurgical department of Gabriel Touré Hospital from September 2017 to August 2018. A detailed history was obtained from the family at presentation. The family history and medical information before and during the pregnancy were compiled. Patients underwent complete physical and neurological examinations. Forty-seven (74.60%) patients underwent repair of the MMC and a ventriculoperitoneal shunt was placed in 12 (19%) patients with accompanying hydrocephalus. The risk factors, neurological status, and surgical results have been analyzed. <strong>Results:</strong> Of 63 children with MMC admitted to our neurosurgical department, 34 (54%) were boys and 29 (46%) were girls. Forty (63.49%) patients were the children of marriages of second cousins or closer. The mean age of the fathers was 34 years (16 - 65), while that of mothers was 26 years (16 - 38). The pregnancy was unplanned in all cases. Fourteen (22.22%) mothers had genitourinary infections, 9 (14.3%) had malaria and 57 (90.47%) mothers used analgesics and antibiotics during the pregnancy. Fifty-nine (93.65%) children were born at term, 58 (92%) were delivered via normal spontaneous vaginal delivery, and 5 (8%) via cesarean section. Lumbosacral lesions were the most frequent in 27 (42.86%) patients. Forty-seven (74.60%) patients underwent repair of the MMC and a ventriculoperitoneal shu<strong>Background:</strong> Myelomeningocele (MMC) is the most common neural tube defect (NTD) characterized by the extrusion of the spinal cord into a sac filled with cerebrospinal fluid, resulting in lifelong disability. In the general population, the incidence of MMC ranges from 0.3 to 4.5/10,000 births. Live born infants with myelomeningocele have a death rate of approximately 10%. Many factors may play a role in the development of MMC such as environmental and genetic factors. In this study, we present our experience with a group of 63 children afflicted with MMC. <strong>Methods:</strong> This study was a retrospective analysis of 63 patients with MMC admitted to the neurosurgical department of Gabriel Touré Hospital from September 2017 to August 2018. A detailed history was obtained from the family at presentation. The family history and medical information before and during the pregnancy were compiled. Patients underwent complete physical and neurological examinations. Forty-seven (74.60%) patients underwent repair of the MMC and a ventriculoperitoneal shunt was placed in 12 (19%) patients with accompanying hydrocephalus. The risk factors, neurological status, and surgical results have been analyzed. <strong>Results:</strong> Of 63 children with MMC admitted to our neurosurgical department, 34 (54%) were boys and 29 (46%) were girls. Forty (63.49%) patients were the children of marriages of second cousins or closer. The mean age of the fathers was 34 years (16 - 65), while that of mothers was 26 years (16 - 38). The pregnancy was unplanned in all cases. Fourteen (22.22%) mothers had genitourinary infections, 9 (14.3%) had malaria and 57 (90.47%) mothers used analgesics and antibiotics during the pregnancy. Fifty-nine (93.65%) children were born at term, 58 (92%) were delivered via normal spontaneous vaginal delivery, and 5 (8%) via cesarean section. Lumbosacral lesions were the most frequent in 27 (42.86%) patients. Forty-seven (74.60%) patients underwent repair of the MMC and a ventriculoperitoneal shu

关 键 词：MYELOMENINGOCELE Neural Tube Defects HYDROCEPHALUS 

分 类 号：R73[医药卫生—肿瘤]