Uterine Rupture in an Unscarred Uterus Following Induced Labor with Titrated Oral Misoprostol  

作　　者：William Ceurvels Shi-Yann Cheng 

机构地区：[1]College of Chinese Medicine, China Medical University, Taiwan [2]School of Medicine, China Medical University, Taiwan [3]Department of Obstetrics and Gynecology, China Medical University Beigang Hospital, Taiwan

出　　处：《Open Journal of Obstetrics and Gynecology》2015年第14期795-798,共4页妇产科期刊（英文）

摘　　要：Misoprostol (Cytotec, Pfizer) is a prostaglandin E1 analogue widely used in labor induction. Understanding of potential risks of misoprostol in labor induction is lacking as the drug is used off-label in most countries. A 35-year-old G3P2 woman with post-date pregnancy at 40 + 3 weeks was induced using titrated oral misoprostol. Following delivery, post-partum hemorrhage was noted and, upon discovery of a uterine wall rupture due to congenital weakness of the myometrium, emergency abdominal total hysterectomy was conducted. Following surgery, the patient made a full recovery and was discharged. The main contraindications for misoprostol in labor induction are a scarred uterus or multipara greater than 4. Uterine wall weakness should be considered as a potential contraindication. Extreme vigilance is required in use of misoprostol for labor induction.Misoprostol (Cytotec, Pfizer) is a prostaglandin E1 analogue widely used in labor induction. Understanding of potential risks of misoprostol in labor induction is lacking as the drug is used off-label in most countries. A 35-year-old G3P2 woman with post-date pregnancy at 40 + 3 weeks was induced using titrated oral misoprostol. Following delivery, post-partum hemorrhage was noted and, upon discovery of a uterine wall rupture due to congenital weakness of the myometrium, emergency abdominal total hysterectomy was conducted. Following surgery, the patient made a full recovery and was discharged. The main contraindications for misoprostol in labor induction are a scarred uterus or multipara greater than 4. Uterine wall weakness should be considered as a potential contraindication. Extreme vigilance is required in use of misoprostol for labor induction.

关 键 词：LABOR Induction MISOPROSTOL POST-PARTUM HEMORRHAGE UTERINE RUPTURE 

分 类 号：R73[医药卫生—肿瘤]