Oxytocin Abuse and Postpartum Hemorrhage  

作　　者：Loutfi Guennoun Abdelmounaim Mohammed Khouchoua Nouha Nhiri Naouale Biougnache Mohamed Adnane Rhaidouni Ouassila Laouji Fatima El Hadraoui Safae Habib Rabbi Omar El Ayoubi Omar Alaoui Samir Messnan Said Lafkir Loutfi Guennoun Abdelmounaim;Mohammed Khouchoua;Nouha Nhiri;Naouale Biougnache;Mohamed Adnane Rhaidouni;Ouassila Laouji;Fatima El Hadraoui;Safae Habib Rabbi;Omar El Ayoubi;Omar Alaoui;Samir Messnan;Said Lafkir(The Head of Pol, Mother and Child Department in Sidi Said Hospital, Meknes, Morocco;Prefectorial Epidemiology Cell, Ministry of Health, Meknes, Morocco;Gynecology and Obstetrics Department, Pagnon Hospital, Meknes, Morocco;The Head Midwives of Two Teams in Pagnon Hospital, Meknes, Morocco;Master in Communication, Moulay Ismail University, Meknes, Morocco;Medical Administration and Epidemiological Services, Meknes, Morocco)

机构地区：[1]The Head of Pol, Mother and Child Department in Sidi Said Hospital, Meknes, Morocco [2]Prefectorial Epidemiology Cell, Ministry of Health, Meknes, Morocco [3]Gynecology and Obstetrics Department, Pagnon Hospital, Meknes, Morocco [4]The Head Midwives of Two Teams in Pagnon Hospital, Meknes, Morocco [5]Master in Communication, Moulay Ismail University, Meknes, Morocco [6]Medical Administration and Epidemiological Services, Meknes, Morocco

出　　处：《Open Journal of Obstetrics and Gynecology》2022年第12期1320-1327,共8页妇产科期刊（英文）

摘　　要：Among the most consolidated dogmas in obstetrics, we have the essential role of oxytocin during: labor by regulating, consolidating uterine contractions, by supporting the expulsive efforts of the patient during childbirth and after childbirth by preventing postpartum hemorrhage. But what challenged us to conduct our study is the large and increasing number of surgical operations for postpartum hemorrhage in patients who received oxytocin during labor. We assumed that the generalization use of oxytocin in all patients during labor is probably responsible of this increasing rate of incidents. To verify this assumption, we carried out a prospective randomized comparative study, involving 3990 pregnant patients admitted at the start of labor at term, with no contraindication for giving birth by normal ways, during a period of 10 months (January-October 2022). The patients have been divided into 2 groups. The first group comprises 1991 patients who were placed on admission on a glucose serum infusion with 4 ampoules of a non-anticholinergic musculotropic antispasmodic: “Hydrated phloroglucinol + trimethylphloroglucinol” (Each ampoule contains 40 mg of hydrated phloroglucinol and 0.04 mg of trimethylphloroglucinol) instead of receiving oxytocin during the active phase of their labor and a second group consisting of 1999 patients who received oxytocin during the active phase of their labor. The results were very surprising and contrary to the already consolidated evidence in our specialty. Indeed, the rate of postpartum hemorrhages was 10 patients (0.5%) in the 1st group vs 30 patients (1.5%) in the 2nd group, 9 patients (0.4%) presented fetal heart rate abnormalities in the 1st group vs 90 (4.5%) in the 2nd group, 8 cases (0.4%) of dynamic dystocia in the 1st group vs 132 cases (6.6%) in the 2nd group and 99 caesareans (5%) in the 1st group vs 299 (15%) in the 2nd group. Against all expectations the results were very surprising, with more details in the article.Among the most consolidated dogmas in obstetrics, we have the essential role of oxytocin during: labor by regulating, consolidating uterine contractions, by supporting the expulsive efforts of the patient during childbirth and after childbirth by preventing postpartum hemorrhage. But what challenged us to conduct our study is the large and increasing number of surgical operations for postpartum hemorrhage in patients who received oxytocin during labor. We assumed that the generalization use of oxytocin in all patients during labor is probably responsible of this increasing rate of incidents. To verify this assumption, we carried out a prospective randomized comparative study, involving 3990 pregnant patients admitted at the start of labor at term, with no contraindication for giving birth by normal ways, during a period of 10 months (January-October 2022). The patients have been divided into 2 groups. The first group comprises 1991 patients who were placed on admission on a glucose serum infusion with 4 ampoules of a non-anticholinergic musculotropic antispasmodic: “Hydrated phloroglucinol + trimethylphloroglucinol” (Each ampoule contains 40 mg of hydrated phloroglucinol and 0.04 mg of trimethylphloroglucinol) instead of receiving oxytocin during the active phase of their labor and a second group consisting of 1999 patients who received oxytocin during the active phase of their labor. The results were very surprising and contrary to the already consolidated evidence in our specialty. Indeed, the rate of postpartum hemorrhages was 10 patients (0.5%) in the 1st group vs 30 patients (1.5%) in the 2nd group, 9 patients (0.4%) presented fetal heart rate abnormalities in the 1st group vs 90 (4.5%) in the 2nd group, 8 cases (0.4%) of dynamic dystocia in the 1st group vs 132 cases (6.6%) in the 2nd group and 99 caesareans (5%) in the 1st group vs 299 (15%) in the 2nd group. Against all expectations the results were very surprising, with more details in the article.

关 键 词：OXYTOCIN ANTISPASMODIC Postpartum Hemorrhage Uterine Inertia Dynamic Dystocia Cesarean Section Abnormal Fetal Heart Rate 

分 类 号：R73[医药卫生—肿瘤]