Altered Levels of Blood Glucose and Serum Lipids in Sudanese Patients with Ovarian Cancer  

作　　者：Maysoon A. Hassaan Atif H. Khirelsied Tagelsir M. Ali Ahmed A. Agab-Aldour Maysoon A. Hassaan;Atif H. Khirelsied;Tagelsir M. Ali;Ahmed A. Agab-Aldour(Department of Biochemistry, Faculty of Medicine, Kordofan University, El-Obeid, Sudan;Department of Biochemistry, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia;Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia;Department of Pathology, Faculty of Medicine, Kordofan University, El-Obeid, Sudan)

机构地区：[1]Department of Biochemistry, Faculty of Medicine, Kordofan University, El-Obeid, Sudan [2]Department of Biochemistry, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia [3]Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia [4]Department of Pathology, Faculty of Medicine, Kordofan University, El-Obeid, Sudan

出　　处：《Open Journal of Obstetrics and Gynecology》2023年第5期896-906,共11页妇产科期刊（英文）

摘　　要：Background: The etiology of ovarian cancer is not well-understood;numerous metabolomics profiling, epidemiological, and hospital-based case control studies have associated abnormal levels of blood glucose and serum lipids with the risk and the prognosis of various types of cancers including ovarian cancer. The association between the risk of the incidence of ovarian cancer and the alterations in the levels of blood glucose and serum lipids is not well defined. Objective: In this study we aimed to compare the levels of blood glucose, triacylglycerols, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in patients with different stages of ovarian cancer and healthy controls to determine how they relate to the risk and prognosis of ovarian cancer. Methodology: In a case-control cross sectional study, we enrolled ninety-nine Sudanese women, diagnosed with ovarian cancer but had not received any kind of treatment as the study group, and a control group of forty-one age-matched, apparently healthy women. The patients were classified according to the International Federation of Obstetricians and Gynecologists staging system into two groups: early stages (stage I & II) and late stages (stages III & IV). Blood glucose and serum lipids;triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol were determined by enzymatic colorimetric methods using commercially available analytical kits. The IBM SPSS version 20 software was used for statistical analysis. A Mann-Whitney U test was used for comparison of the median concentrations of blood glucose, triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the study groups. Logistic regression model was used to estimate the relative risk of ovarian cancer in relation to levels of blood glucose and serum lipids. P value of 0.05 was considered significant. Results: Our data indicated significantly higher levels of blood glucose (p < 0.001),Background: The etiology of ovarian cancer is not well-understood;numerous metabolomics profiling, epidemiological, and hospital-based case control studies have associated abnormal levels of blood glucose and serum lipids with the risk and the prognosis of various types of cancers including ovarian cancer. The association between the risk of the incidence of ovarian cancer and the alterations in the levels of blood glucose and serum lipids is not well defined. Objective: In this study we aimed to compare the levels of blood glucose, triacylglycerols, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol in patients with different stages of ovarian cancer and healthy controls to determine how they relate to the risk and prognosis of ovarian cancer. Methodology: In a case-control cross sectional study, we enrolled ninety-nine Sudanese women, diagnosed with ovarian cancer but had not received any kind of treatment as the study group, and a control group of forty-one age-matched, apparently healthy women. The patients were classified according to the International Federation of Obstetricians and Gynecologists staging system into two groups: early stages (stage I & II) and late stages (stages III & IV). Blood glucose and serum lipids;triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol were determined by enzymatic colorimetric methods using commercially available analytical kits. The IBM SPSS version 20 software was used for statistical analysis. A Mann-Whitney U test was used for comparison of the median concentrations of blood glucose, triacylglycerols, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol in the study groups. Logistic regression model was used to estimate the relative risk of ovarian cancer in relation to levels of blood glucose and serum lipids. P value of 0.05 was considered significant. Results: Our data indicated significantly higher levels of blood glucose (p < 0.001),

关 键 词：Blood Glucose CHOLESTEROL Ovarian Cancer Serum Lipids TRIACYLGLYCEROL 

分 类 号：R73[医药卫生—肿瘤]