Pulmonary Fibrosis Due to Nitrofurantoin Therapy: A Case Report  

作　　者：Leonidas Grigorakos Garyphallia Poulakou Daria Lazarescu Pavlos Myrianthefs Nikolaos Markou Maria Bikou Adamantia Petineli Konstantinos Kokkinis 

机构地区：[1]Faculty of Nursing, National and Kapodistrian University of Athens, Athens, Greece [2]Intensive Care, “KAT” Trauma Hospital of Athens, Athens, Greece [3]Fourth Department of Internal Medicine, Infectious Disease Unit, Attikon University General Hospital of Athens, Athens, Greece [4]Radiology Department, “KAT” Trauma Hospital of Athens, Athens, Greece

出　　处：《Open Journal of Respiratory Diseases》2017年第3期117-124,共8页呼吸病期刊（英文）

摘　　要：We report the case of a patient with pulmonary fibrosis, developed as an adverse reaction to nitrofurantoin therapy received for totally 6 months for the prevention of recurrent urinary tract infections. Chest X-ray and CT scan revealed extensive elements of interstitial pulmonary fibrosis. After diagnosis, administration of nitrofurantoin was immediately stopped;and specific prolonged therapy with low-dose corticosteroids per os and inhaled steroids were administered. The patient responded successfully both clinically and biochemically and possible digestive system side effects were prevented through the administration of gastroprotection medication. For the prevention of urinary tract infection, the patient received well tolerated therapy with fosfomycin which was further continued as a prophylactic agent.We report the case of a patient with pulmonary fibrosis, developed as an adverse reaction to nitrofurantoin therapy received for totally 6 months for the prevention of recurrent urinary tract infections. Chest X-ray and CT scan revealed extensive elements of interstitial pulmonary fibrosis. After diagnosis, administration of nitrofurantoin was immediately stopped;and specific prolonged therapy with low-dose corticosteroids per os and inhaled steroids were administered. The patient responded successfully both clinically and biochemically and possible digestive system side effects were prevented through the administration of gastroprotection medication. For the prevention of urinary tract infection, the patient received well tolerated therapy with fosfomycin which was further continued as a prophylactic agent.

关 键 词：NITROFURANTOIN LUNG TOXICITY FIBROSIS FOSFOMYCIN 

分 类 号：R5[医药卫生—内科学]