Stimulation of Phagocytosis and Production of Antibodies against Canine Herpesvirus Type 1 by Pidotimod (Adimod^TM)  

作　　者：Edgar G. Valdivia Lara Andrés ángeles Aldana Jesica I. ángeles Solis Patricia Miranda Castro Juan C. Del Río García Guillermo Valdivia Anda 

机构地区：[1]Laboratory of Microbial Pathogenicity, Multidisciplinary Research Unit, Faculty of Higher Education Cuautitlán, National Autonomous University of Mexico, Cuautitlán Izcalli, Mexico [2]Laboratory DIVETTM, Cuautitlan Izcalli, Mexico [3]Biotechnology Laboratory, UNAM, Cuautitlan Izcalli, Mexico [4]Laboratory of Mycotoxins, Multidisciplinary Research Unit, Faculty of Higher Education Cuautitlan, National Autonomous University of Mexico, Cuautitlan Izcalli, Mexico

出　　处：《Open Journal of Veterinary Medicine》2017年第4期38-47,共10页兽医学（英文）

摘　　要：Neutrophils are the most important circulating phagocytes. Circulating mono-cytes and precursors of tissue macrophages also have the ability to phagocytize. Pidotimod (ADIMODTM) exerts immunostimulatory and immunoregulatory effects through the stimulation and regulation of cellular immune responses by lymphocytes Canine herpesvirus (CHV) mainly affect puppies between the first and second weeks of age, causing high morbidity in the litter. To date, there is only one commercial vaccine in Europe to prevent disease. In this work, inactivated CHV cultures were inoculated in rabbits, adsorbed and not adsorbed to chitosan nanoparticles. Phagocytosis in the presence or absence of specific antibodies was measured. Response of virus neutralizing antibodies was also evaluated. AdimodTM enhanced the nonspecific and specific phagocytotic response. The association of the virus to the nanoparticles increased the phagocytic ability of blood cells;however, AdimodTM alone had a greater effect on phagocytic activity and generated a stronger immune response that corresponded to the increased phagocytosis (p TM was used.Neutrophils are the most important circulating phagocytes. Circulating mono-cytes and precursors of tissue macrophages also have the ability to phagocytize. Pidotimod (ADIMODTM) exerts immunostimulatory and immunoregulatory effects through the stimulation and regulation of cellular immune responses by lymphocytes Canine herpesvirus (CHV) mainly affect puppies between the first and second weeks of age, causing high morbidity in the litter. To date, there is only one commercial vaccine in Europe to prevent disease. In this work, inactivated CHV cultures were inoculated in rabbits, adsorbed and not adsorbed to chitosan nanoparticles. Phagocytosis in the presence or absence of specific antibodies was measured. Response of virus neutralizing antibodies was also evaluated. AdimodTM enhanced the nonspecific and specific phagocytotic response. The association of the virus to the nanoparticles increased the phagocytic ability of blood cells;however, AdimodTM alone had a greater effect on phagocytic activity and generated a stronger immune response that corresponded to the increased phagocytosis (p TM was used.

关 键 词：PHAGOCYTOSIS CANINE HERPESVIRUS PIDOTIMOD STIMULATION 

分 类 号：R73[医药卫生—肿瘤]