Radioiodination of Cephalexin with ¹²⁵I and Its Biological Behavior in Mice  

作　　者：A.Abd El-Bary A.M. Amin A. El-wetery S. Saad M. Shoukry 

机构地区：[1]不详

出　　处：《Pharmacology & Pharmacy》2012年第1期97-102,共6页药理与制药（英文）

摘　　要：A procedure for radioiodination of Cephalexin with iodine-125 was carried out via an electrophilic substitution reaction. Using 3.7 MBq of Na125I, 200μl of cephalexin as substrate, 200 μl of iodogen as oxidizing agent in acetone at 40°C for 20 min, a maximum radiochemical yield of 125I-Ceph (95%) was obtained. The labeled compound was separated and purified by means of high-pressure liquid chromatography (HPLC). The biological distribution in normal and inflamed (septic and aseptic) mice indicates the suitability of radioiodinated cephalexin for imaging ofA procedure for radioiodination of Cephalexin with iodine-125 was carried out via an electrophilic substitution reaction. Using 3.7 MBq of Na125I, 200μl of cephalexin as substrate, 200 μl of iodogen as oxidizing agent in acetone at 40°C for 20 min, a maximum radiochemical yield of 125I-Ceph (95%) was obtained. The labeled compound was separated and purified by means of high-pressure liquid chromatography (HPLC). The biological distribution in normal and inflamed (septic and aseptic) mice indicates the suitability of radioiodinated cephalexin for imaging of inflammation

关 键 词：CEPHALEXIN Na125I ELECTROPHILIC SUBSTITUTION Reaction RADIOIODINATION INFLAMMATION 

分 类 号：R73[医药卫生—肿瘤]