Immobility Responses Affected by Potassium in Old Rats  

作　　者：Linda Garces-Ramirez Oscar OMorales-Dionisio Gonzalo Flores JoseLuna-Munoz Fidel de la Cruz Linda Garcés-Ramírez;Oscar O. Morales-Dionisio;Gonzalo Flores;José Luna-Muñoz;Fidel de la Cruz(Departamento de Fisiología “Mauricio Russek Berman”, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México;Laboratorio de Neuropsiquiatría, Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, México;National Dementia BioBank, Ciencias Biológicas, Facultad de Estudios Superiores, Cuautitlán, UNAM, Estado de México, México;Departamento de Fisiología “Mauricio Russek Berman”, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México;Banco Nacional de Cerebros-UNPHU, Universidad Nacional Pedro Hernríquez Ure?a, Santo Domingo, República Dominicana)

机构地区：[1]Departamento de Fisiologia“Mauricio Russek Berman”,Escuela Nacional de Ciencias Biologicas,Instituto Politecnico Nacional,Ciudad de Mexico,Mexico [2]Laboratorio de Neuropsiquiatria,Instituto de Fisiologia,Benemerita Universidad Autonoma de Puebla,Puebla,Mexico [3]National Dementia BioBank,Ciencias Biologicas,Facultad de Estudios Superiores,Cuautitlan,UNAM,Estado de Mexico,Mexico [4]Banco Nacional de Cerebros-UNPHU,Universidad Nacional Pedro Hernriquez Urena,Santo Domingo,Republica Dominicana

出　　处：《Pharmacology & Pharmacy》2020年第9期235-250,共16页药理与制药（英文）

摘　　要：Four immobility responses (IR): elicited by clamping, bandaging, grasping and inversion, and their modification by potassium and spironolactone w</span><span style="font-family:Verdana;">as</span><span style="font-family:Verdana;"> studied in old Wistar rats (body weight, 500 g). When undrugged, only clamping and grasping, but not bandaging and inversion induced an IR in rats. Potassium and spironolactone significantly enhanced the duration of IR induced by clamping but not by grasping. They also induced an immobility response by bandaging, but not by inversion. The data suggest that IR induced by clamping and bandaging are somehow related </span><span style="font-family:Verdana;">to</span><span style="font-family:Verdana;"> changes in the potassium serum levels. Consequently, such a relationship may be a suitable model to study some forms of paralysis in human beings which are related to changes in the potassium serum levels.Four immobility responses (IR): elicited by clamping, bandaging, grasping and inversion, and their modification by potassium and spironolactone w</span><span style="font-family:Verdana;">as</span><span style="font-family:Verdana;"> studied in old Wistar rats (body weight, 500 g). When undrugged, only clamping and grasping, but not bandaging and inversion induced an IR in rats. Potassium and spironolactone significantly enhanced the duration of IR induced by clamping but not by grasping. They also induced an immobility response by bandaging, but not by inversion. The data suggest that IR induced by clamping and bandaging are somehow related </span><span style="font-family:Verdana;">to</span><span style="font-family:Verdana;"> changes in the potassium serum levels. Consequently, such a relationship may be a suitable model to study some forms of paralysis in human beings which are related to changes in the potassium serum levels.

关 键 词：Immobility Responses (IR) POTASSIUM SPIRONOLACTONE HYPERKALEMIA Familial Periodic Paralysis 

分 类 号：R73[医药卫生—肿瘤]