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Prognostic implications of overt congestion in heart failure with preserved ejection fraction and the interaction with spironolactone:Insights from TOPCAT
《Chinese Medical Journal》2024年第10期1249-1251,共3页Yingwen Lin Hengli Zhao Dongtu Hu Jia Huang You Peng Juncong Li Dingli Xu Qingchun Zeng 
National Natural Science Foundation of China(Nos.82070403 and 82270374);Science and Technology Program of Guangdong Province(No.2021A0505030031);Frontier Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(No.2018GZR110105001);Youth Science and Technology Innovation Talent Program of Guangdong TeZhi plan(No.2019TQ05Y136)
To the Editor:Heart failure with preserved ejection fraction(HFpEF)is a clinical entity characterized by impaired diastolic function.Until recently,there have been few studies directly evaluating how volume status imp...
关键词：function. FRACTION IMPAIRED 
The Effect of Spironolactone Loading on the Properties of 3D-Printed Polycaprolactone/Gold Nanoparticles Composite Scaffolds for Myocardial Tissue Engineering
《Journal of Bionic Engineering》2024年第2期924-937,共14页Sharareh Ghaziof Shahrokh Shojaei Mehdi Mehdikhani Mohammad Khodaei Milad Jafari Nodoushan 
Engineered cardiac constructs(ECC)aid in the progression of regenerative medicine,disease modeling and targeted drug delivery to adjust and aim the release of remedial combination as well as decrease the side effects ...
关键词：POLYCAPROLACTONE Gold nanoparticles Drug delivery systems SPIRONOLACTONE Cell behavior MYOBLASTS 
Dapagliflozin and Spironolactone Improved Clinical Symptoms and CV Outcomes in Patient with HF Preserved Ejection Fraction (HFpEF) in Hard-to-Reach Rural African Population: A Case Series
《Case Reports in Clinical Medicine》2022年第11期465-473,共9页Dominick Mkombozi Raphael Abdu Hussein Mogella Elias Edrick Mtalemwa Beatrice Kabuka 
Objective: To observe the benefit of mineralocorticoid receptor antagonist and sodium-glucose co-transport 2 inhibitor (SGLT2 inhibitor) in heart failure preserved ejection (HFpEF) in rural Tanzania. Background and Re...
关键词：HFpEF SPIRONOLACTONE DAPAGLIFLOZIN Africans Population 
Analysis of the Clinical Effect of Low-dose Spironolactone on Patients with Severe Heart Failure
《外文科技期刊数据库(文摘版)医药卫生》2022年第8期038-042,共5页WANGJianchang 
Objective: to study the application effect of low-dose spironolactone in patients with severe heart failure. Methods: 150 patients with severe heart failure who were treated in the second department of cardiology in h...
关键词：SPIRONOLACTONE heart failure clinical efficacy 
The effect of spironolactone on the levels of GATA4 protein and hypoxia inducible factor-1α in patients receiving coronary stent implantation
《Journal of Chinese Pharmaceutical Sciences》2022年第2期134-141,共8页Yumei Lou Xiaoying Ge Zhelan Zheng Linyuan Xie Jiangfang Lian Wenjun Shen Kenan Lou Wanying Hu Dexing Hu 
Natural Science and Technology Fund of Ningbo Science and Technology Bureau(Grant No.2017A610203);Yangtze River research project for sustainable development of hospitals in Zhejiang Province(Grant No.2020ZHA-YZJ102)。
In the present study,we aimed to explore the protective effect of spironolactone on cardiac function in patients undergoing coronary stent implantation by determining the serum levels of GATA4 and hypoxia-inducible fa...
关键词：Coronary stent implantation SPIRONOLACTONE Hypoxia-inducible factor-1α GATA4 protein Ischemic cardiomyopathy Global longitudinal strain 
Sequential Combination Diuretic-Therapy for Massive Fluid Overload in Furosemide-Refractory Patients with Diabetic Kidney Disease
《Open Journal of Nephrology》2021年第2期265-272,共8页Kamel El-Reshaid Shaikha Al-Bader 
Patients with renal disease are at risk of fluid overload which escalates as the disease progresses. In the present study, we evaluated the efficacy of sequential combination diuretic-therapy (SCDT) in management of m...
关键词：Aldactone Diabetes Mellitus ECHOCARDIOGRAPHY Fluid Overload FUROSEMIDE HYDROCHLOROTHIAZIDE Kidney Disease Metolazone SPIRONOLACTONE 
Application Effect Evaluation of Telmisartan combined with Spironolactone after Catheter Ablation of Patients with Paroxysmal Atrial Fibrillation
《Journal of Clinical and Nursing Research》2021年第3期135-139,共5页Rongcheng Zhao Jia Han Lei Zhao 
Observational study on effect of transcatheter radiofrequency ablation on patients with different types of atrial fibrillation(Project No.:172302089)。
Objective:To evaluate the application effect of telmisartan combined with spironolactone after catheter ablation of patients with paroxysmal atrial fibrillation.Methods:80 cases of patients with paroxysmal atrial fibr...
关键词：Paroxysmal atrial fibrillation Catheter ablation Telmisartan combined with spironolactone Application effect 
Immobility Responses Affected by Potassium in Old Rats
《Pharmacology & Pharmacy》2020年第9期235-250,共16页Linda Garces-Ramirez Oscar OMorales-Dionisio Gonzalo Flores JoseLuna-Munoz Fidel de la Cruz 
Four immobility responses (IR): elicited by clamping, bandaging, grasping and inversion, and their modification by potassium and spironolactone was
《Journal of Cosmetics, Dermatological Sciences and Applications》2019年第3期216-222,共7页Yohei Tanaka Toru Aso Jumpei Ono 
Background: Hair loss in women has a various psychosocial impact and effective treatments have been required. Camouflaging products which cover exposed areas on the scalp and hide visible hair loss are common, but med...
关键词：Combination Therapy FEMALE Patternhair LOSS (FPHL) MINOXIDIL SPIRONOLACTONE 
Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability被引量：2
《Asian Journal of Pharmaceutical Sciences》2019年第1期95-103,共9页Zhaomeng Wang Mengchi Sun Tian Liu Zisen Gao Qing Ye Xiao Tan Yanxian Hou Jin Sun Dun Wang Zhonggui He 
financially supported by the National Basic Research Program of China(973 Program,No.2015CB932100);the National Nature Science Foundation of China(No.81473164);Key projects of Liaoning Province Department of Education(No.2017LZD03)。
Co-amorphous solid dispersion(C-ASD)systems have attracted great attention to improve the solubility of poorly soluble drugs,but the selection of an appropriate stabilizer to stabilize amorphous forms is still a huge ...
关键词：Co-amorphous solid DISPERSION LACIDIPINE SPIRONOLACTONE Stability Molecular dynamic(MD) simulations 
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