Clinical Assessment of a Pharmaceutical Polyphenol Fruit Extract Gel to Inhibit Dental Plaque  

作　　者：Steven P. Goh David M. Goh E. Russell Vickers Steven P. Goh;David M. Goh;E. Russell Vickers(Suite 1, 76A Archer St, Chatswood, NSW 2067, Australia;Clinical Stem Cells, Sydney, Australia)

机构地区：[1]Suite 1, 76A Archer St, Chatswood, NSW 2067, Australia [2]Clinical Stem Cells, Sydney, Australia

出　　处：《Pharmacology & Pharmacy》2021年第9期177-189,共13页药理与制药（英文）

摘　　要：<span style="font-family:""><span style="font-family:Verdana;">Oral bacteria (e.g. </span><i><span style="font-family:Verdana;">Porphyromonas gingivalis</span></i><span style="font-family:Verdana;">) are associated and potentially co-causative in several medical conditions including Alzheimer’s disease and increased cardiovascular risk. Naturally occurring polyphenols are a developing class of antimicrobial pharmaceutical agents. The use of plant-based</span><span style="color:red;"> </span><span style="font-family:Verdana;">polyphenol compounds is an attractive area of medical and dental research due to their high safety factor from their presence in vegetables and fruits. This preliminary study evaluated polyphenols found in berries to reduce bacterial dental plaque accumulation. The study was an </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> single blind randomized controlled trial of seven subjects with a novel tooth gel using validated measurements. Results showed a significant reduction in plaque accumulation (p</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.005) and a non-significant trend to reduce gingivitis (p</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.08). The bioactive gel showed no local or systemic adverse effects and was well tolerated by subjects.<span style="font-family:""><span style="font-family:Verdana;">Oral bacteria (e.g. </span><i><span style="font-family:Verdana;">Porphyromonas gingivalis</span></i><span style="font-family:Verdana;">) are associated and potentially co-causative in several medical conditions including Alzheimer’s disease and increased cardiovascular risk. Naturally occurring polyphenols are a developing class of antimicrobial pharmaceutical agents. The use of plant-based</span><span style="color:red;"> </span><span style="font-family:Verdana;">polyphenol compounds is an attractive area of medical and dental research due to their high safety factor from their presence in vegetables and fruits. This preliminary study evaluated polyphenols found in berries to reduce bacterial dental plaque accumulation. The study was an </span><i><span style="font-family:Verdana;">in vivo</span></i><span style="font-family:Verdana;"> single blind randomized controlled trial of seven subjects with a novel tooth gel using validated measurements. Results showed a significant reduction in plaque accumulation (p</span></span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.005) and a non-significant trend to reduce gingivitis (p</span><span style="font-family:""> </span><span style="font-family:Verdana;">=</span><span style="font-family:""> </span><span style="font-family:Verdana;">0.08). The bioactive gel showed no local or systemic adverse effects and was well tolerated by subjects.

关 键 词：Dental Plaque GINGIVITIS POLYPHENOL QUERCETIN Randomized Controlled Trial 

分 类 号：R78[医药卫生—口腔医学]