Mast Cells:The Key to Multiple Sclerosis?  

作　　者：Per Goran Krüger 

机构地区：[1]Institute of Biomedicine,University of Bergen,Bergen,Norway

出　　处：《World Journal of Neuroscience》2014年第2期120-124,共5页神经科学国际期刊（英文）

摘　　要：Mast cells are present in high numbers in the border-zones of the multiple sclerosis-plaques. They are located in small clusters along capillaries and venules, and they are more abundant in females than in men. Mast cells can be stimulated to release specific mediators such as histamine, resulting in oedema formation, as well as proteases that may cause demyelination, by several different activation mechanisms. We hypothesize that a putative mast cell activation may be induced by diet factor(s) as well as long lasting mental stress that may lead to the release of catestatin, as well as ACTH released from the pituitary gland. Given a natural flux of mast cell recovery and activation, a putative phenomenon of massive release of mediators and “silent” reload periods may explain the relapsing-remitting phases of multiple sclerosis.Mast cells are present in high numbers in the border-zones of the multiple sclerosis-plaques. They are located in small clusters along capillaries and venules, and they are more abundant in females than in men. Mast cells can be stimulated to release specific mediators such as histamine, resulting in oedema formation, as well as proteases that may cause demyelination, by several different activation mechanisms. We hypothesize that a putative mast cell activation may be induced by diet factor(s) as well as long lasting mental stress that may lead to the release of catestatin, as well as ACTH released from the pituitary gland. Given a natural flux of mast cell recovery and activation, a putative phenomenon of massive release of mediators and “silent” reload periods may explain the relapsing-remitting phases of multiple sclerosis.

关 键 词：Multiple Sclerosis Mast Cells HISTAMINE Mast Cell Proteases Socio-Cultural Factors Metabolic Factors Mental Stress CATESTATIN Phtalates FEMALE MALE RELAPSING-REMITTING 

分 类 号：R73[医药卫生—肿瘤]