Photo-Thermal Induced Optical Scattering Modulation Sensor for Malaria Diagnosis  

作　　者：Daniel Maitethia Memeu Merenga Abdallah Sarroney Ciira Maina 

机构地区：[1]Department of Physical Sciences, Meru University of Science and Technology, Meru, Kenya [2]Department of Physics, Kenyatta University, Nairobi, Kenya [3]Dedan Kimathi University of Technology, Nyeri, Kenya

出　　处：《Open Journal of Biophysics》2018年第4期185-193,共9页生物物理学期刊（英文）

摘　　要：Malaria is one of the leading killer diseases in sub-Saharan Africa. Although the disease is curable, early and accurate diagnosis is key to effective therapy. Existing malaria diagnostic techniques have low detection accuracy especially when the parasite load in the blood is low. In this paper, we report on a simple photo-thermal based technique for detection of the Plasmodium parasites’ biomarker (hemozoin) in blood smear samples. The technique has demonstrated 100% Plasmodium detection sensitivity and specificity from the ten blood smear test samples used.Malaria is one of the leading killer diseases in sub-Saharan Africa. Although the disease is curable, early and accurate diagnosis is key to effective therapy. Existing malaria diagnostic techniques have low detection accuracy especially when the parasite load in the blood is low. In this paper, we report on a simple photo-thermal based technique for detection of the Plasmodium parasites’ biomarker (hemozoin) in blood smear samples. The technique has demonstrated 100% Plasmodium detection sensitivity and specificity from the ten blood smear test samples used.

关 键 词：PHOTOTHERMAL INDUCED Optical Scattering MODULATION Photoacoustic Probing HEMOZOIN HEMOGLOBIN Probe BEAM Excitation BEAM 

分 类 号：R73[医药卫生—肿瘤]