Age Does Not Affect the Induction of Mortality by the Foodborne Pathogen <i>Salmonella enterica</i>in <i>Caenorhabditis elegans</i>  

作　　者：Dawn M. F. Burns James M. Harper Aaron M. Lynne 

机构地区：[1]Department of Biological Sciences, Sam Houston State University, Huntsville, TX, USA

出　　处：《Advances in Microbiology》2017年第10期689-695,共7页微生物学（英文）

摘　　要：Salmonella is a common cause of foodborne illness within the United States with the severity of the infection being a factor of both the age and overall health of the infected individual. The nematode worm Caenorhabditis elegans has proven to be a useful model to study infection dynamics of pathogenic bacteria, including Salmonella enterica, and its short lifespan makes it a powerful model system to assess the effect of organismal age on infection severity. In this study, we infected C. elegans with each of 6 serovars of S. enterica at 1, 3 or 5 days of worm age and monitored their survival. Worms infected with E. coli OP50 were used as a control. Infection with S. enterica resulted in a significant reduction in mean longevity relative to OP50 (p < 0.05);however, there was no significant effect of age on mean survival time regardless of the strain of bacteria used.Salmonella is a common cause of foodborne illness within the United States with the severity of the infection being a factor of both the age and overall health of the infected individual. The nematode worm Caenorhabditis elegans has proven to be a useful model to study infection dynamics of pathogenic bacteria, including Salmonella enterica, and its short lifespan makes it a powerful model system to assess the effect of organismal age on infection severity. In this study, we infected C. elegans with each of 6 serovars of S. enterica at 1, 3 or 5 days of worm age and monitored their survival. Worms infected with E. coli OP50 were used as a control. Infection with S. enterica resulted in a significant reduction in mean longevity relative to OP50 (p < 0.05);however, there was no significant effect of age on mean survival time regardless of the strain of bacteria used.

关 键 词：Salmonella ENTERICA CAENORHABDITIS ELEGANS Aging Infection 

分 类 号：R73[医药卫生—肿瘤]