ELEGANS

作品数：158被引量：260H指数：8
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相关作者：杨玉荣王大勇蒋正尧高雅君汪洋更多>>
相关机构：厦门大学东南大学中国科学技术大学山西大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
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Peri-centrosomal localization of small interfering RNAs in C.elegans
《Science China(Life Sciences)》2025年第4期895-911,共17页Qile Jin Xuezhu Feng Minjie Hong Ke Wang Xiangyang Chen Jiewei Cheng Yan Kuang Xiaoyue Si Mingjing Xu Xinya Huang Shouhong Guang Chengming Zhu 
funded by the National Institutes of Health(NIH)Office of Research Infrastructure Programs(P40 OD010440);supported by grants from the National Natural Science Foundation of China(32230016 awarded to S.G.,32270583 awarded to C.Z.,32070619 awarded to X.F.,2023M733425 awarded to X.H.,and 32300438 awarded to X.H.);the National Key R&D Program of China(2022YFA1302700 to S.G.);the Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM(QYPY20230021 awarded to S.G.);the Fundamental Research Funds for the Central Universities。
The centrosome is the microtubule-organizing center and a crucial part of cell division.Centrosomal RNAs(cnRNAs)have been reported to enable precise spatiotemporal control of gene expression during cell division in ma...
关键词：SIRNA centrosomal RNAs NRDE-3 
Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens
《Protein & Cell》2025年第3期161-187,共27页Chao Yang Longfeng Yao Dan Chen Changling Chen Wenbo Li Hua Tong Zihang Cheng Yanling Yan Long Lin Jing Zhang Anbing Shi 
The National Key R&D Program of China(2021YFA1300302);the National Natural Science Foundation of China(32320103007,32130027);the National Science Fund for Distinguished Young Scholars(31825017);the Major Research Plan of the Natural Science Foundation of China(92154001)to A.Shi.
Endosomes are characterized by the presence of various phosphoinositides that are essential for defining the membrane properties.However,the interplay between endosomal phosphoinositides metabolism and innate immunity...
关键词：C.elegans RAB-10/Rab10 UNC-16/JIP3 sorting endosome EGL-8/PLC-β NHR-25/NR5A1/2 PI(4 5)P2 
An effective method for quantification,visualization,and analysis of 3D cell shape during early embryogenesis
《Quantitative Biology》2025年第1期113-126,共14页Zelin Li Zhaoke Huang Jianfeng Cao Guoye Guan Zhongying Zhao Hong Yan 
Embryogenesis is the most basic process in developmental biology.Effectively and simply quantifying cell shape is challenging for the complex and dynamic 3D embryonic cells.Traditional descriptors such as volume,surfa...
关键词：Caenorhabditis elegans(C.elegans) cell shape quantification eigen features(eigengrid eigenharmonic&eigenspectrum) lineage analysis morphological reproducibility spherical harmonics(SPHARM) 
HMG-3 contributes to meiotic chromosome maintenance and inhibits reproductive aging in C. elegans
《Journal of Genetics and Genomics》2024年第12期1509-1512,共4页Fengguo Zhang Yuanyuan Liu Yanmei Li Xiuxiu Liu Yingchun Zhang Guohai Su 
supported by Jinan Municipal Health Commission Science and Technology Project(2023-2-13 to F.Z.);the Joint Fund of the Natural Science Foundation of Shandong Province(ZR2022LZL005 to X.L.);Postdoctoral Innovation Project of Shandong Province(SDCX-ZG-202201001 to X.L.)。
Reproductive aging involves a progressive decline in fertility,particularly in females(Duncan et al.,2018;Gruhn et al.,2019),which is characterized by the decline in the number of follicles and the deterioration of oo...
关键词：aging SEGREGATION COMPLETION 
Characterization of auditory sensation in C.elegans
《Biophysics Reports》2024年第6期351-363,共13页Can Wang Elizabeth A.Ronan Adam J.Iliff Rawan Al-Ebidi Panagiota Kitsopoulos Karl Grosh Jianfeng Liu X.Z.Shawn Xu 
support from NIH T32 training grants;support from an NIH F32 grant;supported by grants from the NIDCD and NIGMS(to X.Z.S.X.)。
Research using the model organism nematode C.elegans has greatly facilitated our understanding of sensory biology,including touch,olfaction,taste,vision and proprioception.While hearing had long been considered to be ...
关键词：C.elegans HEARING AUDITION MECHANOSENSATION MECHANOSENSORY 
Overexpression of Kdm6b induces testicular differentiation in a temperature-dependent sex determination system
《Zoological Research》2024年第5期1108-1115,共8页Qiran Chen Wei Sun Lin Jin Yingjie Zhou Fang Li Chutian Ge 
supported by the National Natural Science Foundation of China(32325049,U22A20529,32303000);Zhejiang Provincial Natural Science Foundation(LQ24C190009);Ningbo Natural Science Foundation(2022J192);Zhejiang Provincial Top Key Discipline of Biological Engineering(1741000592)。
In reptiles,such as the red-eared slider turtle(Trachemys scripta elegans),gonadal sex determination is highly dependent on the environmental temperature during embryonic stages.This complex process,which leads to dif...
关键词：Temperature-dependent sex determination Sex reversal Kdm6b DMRT1 T.s.elegans 
CShaperApp:Segmenting and analyzing cellular morphologies of the developing Caenorhabditis elegans embryo
《Quantitative Biology》2024年第3期329-334,共6页Jianfeng Cao Lihan Hu Guoye Guan Zelin Li Zhongying Zhao Chao Tang Hong Yan 
National Natural Science Foundation of China,Grant/Award Numbers:12090053,32088101;Hong Kong Innovation and Technology Fund,Grant/Award Numbers:GHP/176/21SZ,InnoHK Project CIMDA;Hong Kong Research Grants Council,Grant/Award Numbers:11204821,HKBU12101323,HKBU12101520,HKBU12101522,N_HKBU201/18。
Caenorhabditis elegans has been widely used as a model organism in developmental biology due to its invariant development.In this study,we developed a desktop software CShaperApp to segment fluorescence-labeled images...
关键词：C.elegans embryogenesis cellular morphology cellular segmentation deep learning desktop software 
Dimethylsulfoniopropionate (DMSP) Increases Longevity and Mitochondrial Function in Caenorhabditis elegans: Implications for the Role of the Global Sulfur Cycle in Terrestrial Ecosystems
《Environment & Health》2024年第8期572-585,共14页Hongyuan Li Peng Ji Yue Cao Zhitao Cui Jingwei Gao Hongshuang Wang Cong Lin Yibo Wang Xiaohui Wang 
National Key R&D Program of China(2022YFE0113000);Jilin Provincial Development and Reform Commission(2023C038-3);Brain Science and Brain-Like Intelligence Technology Program(2021ZD0203003);Beijing National Laboratory for Molecular Sciences(BNLMS202108);Chinese Academy of Sciences Pioneer Hundred Talents Program.
Dimethylsulfoniopropionate(DMSP)is a compound synthesized by marine phytoplankton that contributes to the oceanic sulfur cycle.Interestingly,DMSP has also been found in algal species and several terrestrial plants,for...
关键词：DMSP C.elegans terrestrial ecosystem aging autophagy 
C.elegans model of riboflavin transporter deficiency(RTD)disorder reveals deficits in synaptic transmission and movement
《Genes & Diseases》2024年第4期120-123,共4页Ramesh K.Narayanan Gonzalo Perez-siles Kamila A.Marzec Alexandra Boyling Brent Neumann Manoj P.Menezes Marina L.Kennerson 
support was provided by the Cure RTD Foundation and Australian Medical Research Future Fund(MRFF)Genomics Health Futures Mission Grant(No.2007681);funded by the NIH Office of the Research Infrastructure programs(P400D010440).
Riboflavin transporter deficiency(RTD),previously known as Brown-Vialetto-Van Laere syndrome,is a childhoodonset neurodegenerative disorder characterized by sensory and motor neuron degeneration causing ataxia,muscle ...
关键词：RTD DEGENERATION TD 
The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan
《Acta Pharmaceutica Sinica B》2024年第7期3266-3280,共15页Wenfeng Li Shuming Chen Jing Lang Jing Luo Jiahui Chen Liping Zhang Zhijie Sun Deli Dong 
supported by the National Natural Science Foundation of China(Nos.82373864 and 82170472).
The drugs extending healthspan in clinic have always been searched.Nitazoxanide is an FDA-approved clinical antiprotozoal drug.Nitazoxanide is rapidly metabolized to tizoxanide after absorption in vivo.Our previous st...
关键词：NITAZOXANIDE Tizoxanide C.elegans Healthspan LIFESPAN AMPK Akt Mitochondrial uncoupling 
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