ELEGANS

作品数：155被引量：260H指数：8
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相关作者：杨玉荣王大勇蒋正尧高雅君汪洋更多>>
相关机构：厦门大学东南大学中国科学技术大学山西大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金国家高技术研究发展计划更多>>
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Characterization of auditory sensation in C.elegans
《Biophysics Reports》2024年第6期351-363,共13页Can Wang Elizabeth A.Ronan Adam J.Iliff Rawan Al-Ebidi Panagiota Kitsopoulos Karl Grosh Jianfeng Liu X.Z.Shawn Xu 
support from NIH T32 training grants;support from an NIH F32 grant;supported by grants from the NIDCD and NIGMS(to X.Z.S.X.)。
Research using the model organism nematode C.elegans has greatly facilitated our understanding of sensory biology,including touch,olfaction,taste,vision and proprioception.While hearing had long been considered to be ...
关键词：C.elegans HEARING AUDITION MECHANOSENSATION MECHANOSENSORY 
HMG-3 contributes to meiotic chromosome maintenance and inhibits reproductive aging in C. elegans
《Journal of Genetics and Genomics》2024年第12期1509-1512,共4页Fengguo Zhang Yuanyuan Liu Yanmei Li Xiuxiu Liu Yingchun Zhang Guohai Su 
supported by Jinan Municipal Health Commission Science and Technology Project(2023-2-13 to F.Z.);the Joint Fund of the Natural Science Foundation of Shandong Province(ZR2022LZL005 to X.L.);Postdoctoral Innovation Project of Shandong Province(SDCX-ZG-202201001 to X.L.)。
Reproductive aging involves a progressive decline in fertility,particularly in females(Duncan et al.,2018;Gruhn et al.,2019),which is characterized by the decline in the number of follicles and the deterioration of oo...
关键词：aging SEGREGATION COMPLETION 
Overexpression of Kdm6b induces testicular differentiation in a temperature-dependent sex determination system
《Zoological Research》2024年第5期1108-1115,共8页Qiran Chen Wei Sun Lin Jin Yingjie Zhou Fang Li Chutian Ge 
supported by the National Natural Science Foundation of China(32325049,U22A20529,32303000);Zhejiang Provincial Natural Science Foundation(LQ24C190009);Ningbo Natural Science Foundation(2022J192);Zhejiang Provincial Top Key Discipline of Biological Engineering(1741000592)。
In reptiles,such as the red-eared slider turtle(Trachemys scripta elegans),gonadal sex determination is highly dependent on the environmental temperature during embryonic stages.This complex process,which leads to dif...
关键词：Temperature-dependent sex determination Sex reversal Kdm6b DMRT1 T.s.elegans 
CShaperApp:Segmenting and analyzing cellular morphologies of the developing Caenorhabditis elegans embryo
《Quantitative Biology》2024年第3期329-334,共6页Jianfeng Cao Lihan Hu Guoye Guan Zelin Li Zhongying Zhao Chao Tang Hong Yan 
National Natural Science Foundation of China,Grant/Award Numbers:12090053,32088101;Hong Kong Innovation and Technology Fund,Grant/Award Numbers:GHP/176/21SZ,InnoHK Project CIMDA;Hong Kong Research Grants Council,Grant/Award Numbers:11204821,HKBU12101323,HKBU12101520,HKBU12101522,N_HKBU201/18。
Caenorhabditis elegans has been widely used as a model organism in developmental biology due to its invariant development.In this study,we developed a desktop software CShaperApp to segment fluorescence-labeled images...
关键词：C.elegans embryogenesis cellular morphology cellular segmentation deep learning desktop software 
Dimethylsulfoniopropionate (DMSP) Increases Longevity and Mitochondrial Function in Caenorhabditis elegans: Implications for the Role of the Global Sulfur Cycle in Terrestrial Ecosystems
《Environment & Health》2024年第8期572-585,共14页Hongyuan Li Peng Ji Yue Cao Zhitao Cui Jingwei Gao Hongshuang Wang Cong Lin Yibo Wang Xiaohui Wang 
National Key R&D Program of China(2022YFE0113000);Jilin Provincial Development and Reform Commission(2023C038-3);Brain Science and Brain-Like Intelligence Technology Program(2021ZD0203003);Beijing National Laboratory for Molecular Sciences(BNLMS202108);Chinese Academy of Sciences Pioneer Hundred Talents Program.
Dimethylsulfoniopropionate(DMSP)is a compound synthesized by marine phytoplankton that contributes to the oceanic sulfur cycle.Interestingly,DMSP has also been found in algal species and several terrestrial plants,for...
关键词：DMSP C.elegans terrestrial ecosystem aging autophagy 
C.elegans model of riboflavin transporter deficiency(RTD)disorder reveals deficits in synaptic transmission and movement
《Genes & Diseases》2024年第4期120-123,共4页Ramesh K.Narayanan Gonzalo Perez-siles Kamila A.Marzec Alexandra Boyling Brent Neumann Manoj P.Menezes Marina L.Kennerson 
support was provided by the Cure RTD Foundation and Australian Medical Research Future Fund(MRFF)Genomics Health Futures Mission Grant(No.2007681);funded by the NIH Office of the Research Infrastructure programs(P400D010440).
Riboflavin transporter deficiency(RTD),previously known as Brown-Vialetto-Van Laere syndrome,is a childhoodonset neurodegenerative disorder characterized by sensory and motor neuron degeneration causing ataxia,muscle ...
关键词：RTD DEGENERATION TD 
The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan
《Acta Pharmaceutica Sinica B》2024年第7期3266-3280,共15页Wenfeng Li Shuming Chen Jing Lang Jing Luo Jiahui Chen Liping Zhang Zhijie Sun Deli Dong 
supported by the National Natural Science Foundation of China(Nos.82373864 and 82170472).
The drugs extending healthspan in clinic have always been searched.Nitazoxanide is an FDA-approved clinical antiprotozoal drug.Nitazoxanide is rapidly metabolized to tizoxanide after absorption in vivo.Our previous st...
关键词：NITAZOXANIDE Tizoxanide C.elegans Healthspan LIFESPAN AMPK Akt Mitochondrial uncoupling 
Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C.elegans
《Journal of Genetics and Genomics》2024年第5期507-516,共10页Xiao Zang Qi Wang Hanxin Zhang Yiyan Zhang Zi Wang Zixing Wu Di Chen 
the National Key R&D Program of China(2021YFA0805802 to D.C.);the National Natural Science Foundation of China(31971092 and 32171156 to D.C.);Some strains were provided by the Caenorhabditis Genetics Center(CGC),which is funded by NIHOffice of Research Infrastructure Programs(P40 OD010440).
The highly conserved target of rapamycin(TOR)pathway plays an important role in aging across species.Previous studies have established that inhibition of the TOR complex 1(TORC1)significantly extends lifespan in Caeno...
关键词：Aging targetof rapamycin DAF-15 DAF-16 C.elegans 
Exploring lysosomal biology:current approaches and methods
《Biophysics Reports》2024年第2期111-120,共10页Qiuyuan Yin Chonglin Yang 
supported by the National Science Foundation of China(32293200 and32293201);the National Basic Research Program of China(2021YFA1300302);Yunnan Province Science and Technology Department(202001BB050077);supported by the Program of Yunnan Province Leading Talents in Science and Technology(202105AB160003)。
Lysosomes are the degradation centers and signaling hubs in the cell.Lysosomes undergo adaptation to maintain cell homeostasis in response to a wide variety of cues.Dysfunction of lysosomes leads to aging and severe d...
关键词：LYSOSOME Method Cultured cell C.elegans MICE 
Water–soluble and polarity–sensitive near–infrared fluorescent probe for long–time specific cancer cell membranes imaging and C. Elegans label
《Chinese Chemical Letters》2024年第4期321-323,共3页Lixian Fu Yiyun Tan Yue Ding Weixia Qing Yong Wang 
Henan Provincial Science and Technology Research Project (No.232102310369) for financial support。
A novel D–π –A structure and near–infrared fluorescent probe(DCITT) with high polarity sensitivity and membrane targeting was reported. The fluorescent spectra of DCITT were polarity dependent and Stokes shift was...
关键词：NIR–fluorescent probe Polarity–sensitive BIOIMAGING Targeting cell membrane Differentiate tumor and normal cells 
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