NITAZOXANIDE

作品数：14被引量：39H指数：4
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相关领域：医药卫生农业科学更多>>
相关作者：薛飞群尚炜沈一平管晓虹冯振卿更多>>
相关机构：中国农业科学院上海家畜寄生虫病研究所北京农林科学院南京医科大学中国农业科学院更多>>
相关期刊：《中国处方药》《国际医学寄生虫病杂志》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》更多>>
相关基金：国家自然科学基金中国博士后科学基金高等学校学科创新引智计划更多>>
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The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan
《Acta Pharmaceutica Sinica B》2024年第7期3266-3280,共15页Wenfeng Li Shuming Chen Jing Lang Jing Luo Jiahui Chen Liping Zhang Zhijie Sun Deli Dong 
supported by the National Natural Science Foundation of China(Nos.82373864 and 82170472).
The drugs extending healthspan in clinic have always been searched.Nitazoxanide is an FDA-approved clinical antiprotozoal drug.Nitazoxanide is rapidly metabolized to tizoxanide after absorption in vivo.Our previous st...
关键词：NITAZOXANIDE Tizoxanide C.elegans Healthspan LIFESPAN AMPK Akt Mitochondrial uncoupling 
Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice被引量：5
《Acta Pharmaceutica Sinica B》2022年第3期1322-1338,共17页Fengfeng Li Man Jiang Minghui Ma Xuyang Chen Yidan Zhang Yixin Zhang Yuanyuan Yu Yunfeng Cui Jiahui Chen Hui Zhao Zhijie Sun Deli Dong 
supported by the National Natural Science Foundation of China(Nos.81773725 and 91739102)。
Lipid metabolism disorders contribute to hyperlipidemia and hepatic steatosis.It is ideal to develop drugs simultaneous improving both hyperlipidemia and hepatic steatosis.Nitazoxanide is an FDA-approved oral antiprot...
关键词：NITAZOXANIDE Tizoxanide HYPERLIPIDEMIA Hepatic steatosis AMPK Autophagy SQSTM1/P62 Mitochondrial uncoupling 
Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer’s disease被引量：2
《Acta Pharmaceutica Sinica B》2020年第4期646-666,共21页Xiaokang Li Jian Lu Yixiang Xu Jiaying Wang Xiaoxia Qiu Lei Fan Baoli Li Wenwen Liu Fei Mao Jin Zhu Xu Shen Jian Li 
provided by the National Sciences and Technology Major Project of China,(2018ZX09711002-003-010);the National Natural Science Foundation of China,(81872747,21672064);the 111 Project(B07023,China);the Chinese Postdoctoral Science Foundation(2018M641946);the Shanghai Sailing Program(19YF1412600,China);the Shanghai Morning Light Program(18CG33,China);the National Special Fund for State Key Laboratory of Bioreactor Engineering(2060204,China);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX18_1600,China).
Drug repurposing is an efficient strategy for new drug discovery.Our latest study found that nitazoxanide(NTZ),an approved anti-parasite drug,was an autophagy activator and could alleviate the symptom of Alzheimer’s ...
关键词：Alzheimer’s disease AUTOPHAGY NITAZOXANIDE Β-AMYLOID Tau protein 
Nitazoxanide,an anti-parasitic drug,efficiently ameliorates learning and memory impairments in AD model mice被引量：6
《Acta Pharmacologica Sinica》2019年第10期1279-1291,共13页Lei Fan Xiao-xia Qiu Zhi-yuan Zhu Jian-lu Lv Jian Lu Fei Mao Jin Zhu Jia-ying Wang Xiao-wei Guan Jing Chen Jin Ren Ji-ming Ye Yong-hua Zhao Jian Li Xu Shen 
This work was supported by the National Natural Science Foundation of China(grant number 81473141),NSFC-TRF collaboration projects(grant number NSFC81561148011);the Key Laboratory of Receptor Research of the Chinese Academy of Sciences(grant number SIMM1606YZZ-04);Personalized Medicines:Molecular Signature-based Drug Discovery and Development,Strategic Priority Research Program of the Chinese Academy of Sciences(grant number XDA12040303);the Priority Academic Program Development of Jiangsu Higher Education Institutions(Integration of Chinese and Western Medicine).
The pathogenesis of Alzheimer's disease(AD)is characterized by both accumulation ofβ-amyloid(AB)plaque and formation of neurofirillary tangles in the brain.Recent evidence shows that autophagy activation may potently...
关键词：Alzheimer's disease NITAZOXANIDE AUTOPHAGY inflammation APP/PS1 TRANSGENIC MICE 
Introducing nitazoxanide as a promising alternative treatment for symptomatic to metronidazole-resistant giardiasis in clinical isolates
《Asian Pacific Journal of Tropical Medicine》2016年第9期866-871,共6页Tahereh Mikaeili Galeh Abdolhassan Kazemi Mahmoud Mahami-Oskouei Behzad Baradaran Adel Spotin Seddigheh Sarafraz Majid Karamat 
financially supported by Immunology Research Center,Tabriz University of Medical Sciences,Tabriz,Iran;the master’s thesis of the first author(Thesis No.93/2-4/12)
Objective:To identify the frequencies(F) of ferredoxin and nitroreductase mutations were identified on Iranian clinical isolates of Giardia lamblia in order to predict whether the nitazoxanide can be prescribed as sui...
关键词：Giardia LAMBLIA FERREDOXIN oxidoreductase NITROREDUCTASE NITAZOXANIDE METRONIDAZOLE 
Cryptosporidium infection in solid organ transplantation被引量：3
《World Journal of Transplantation》2016年第3期460-471,共12页Diana F Florescu Uriel Sandkovsky 
Diarrhea is a common complication in solid organ transplant(SOT) recipients and may be attributed to immunosuppressive drugs or infectious organisms such as bacteria, viruses or parasites. Cryptosporidium usually caus...
关键词：CRYPTOSPORIDIUM Solid ORGAN TRANSPLANTATION DIARRHEA NITAZOXANIDE ANTIPARASITIC drugs 
Voltammetric quantitation of nitazoxanide by glassy carbon electrode
《Journal of Pharmaceutical Analysis》2013年第6期452-455,共4页Rajeev Jain Rajeev Kumar Yadav Jahangir Ahmad Rather 
The present study reports voltammetric reduction of nitazoxanide in Britton-Robinson （B-R） buffer by cyclic and square-wave voltammetry at glassy carbon electrode. A versatile fully validated voltammetric method for...
关键词：NITAZOXANIDE Squarewave voltammetry Glassy carbon electrode Pharmaceuticalformulation 
Validated stability indicating methods for determination of nitazoxanide in presence of its degradation products被引量：3
《Journal of Pharmaceutical Analysis》2012年第2期105-116,共12页Nouruddin W.Ali Samah Sayed Abbas Hala El-Sayed Zaazaa Maha Mohamed Abdelrahman Mohamed Abdelkawy 
Three sensitive,selective and reproducible stability-indicating methods are presented for determination of nitazoxanide (NTZ),a new anti-protozoal drug,in presence of its degradation products.Method A utilizes the fir...
关键词：NITAZOXANIDE DEGRADATION Derivative spectrophotometry CHEMOMETRICS TLC-DENSITOMETRY Stability-indicating methods 
Treatment of chronic viral hepatitis with nitazoxanide and second generation thiazolides被引量：5
《World Journal of Gastroenterology》2009年第15期1805-1808,共4页Emmet B Keeffe Jean-Franois Rossignol 
Nitazoxanide,the first thiazolide,was originally developed for the treatment of Cryptosporidium parvum.More recently,antiviral activity of nitazoxanide against hepatitis B virus(HBV)and hepatitis C virus was recognize...
关键词：Hepatitis C Hepatitis C virus NITAZOXANIDE 
广谱抗肠道寄生虫药硝唑尼特(nitazoxanide)研究进展被引量：12
《国际医学寄生虫病杂志》2006年第4期221-224,共4页沈一平 管晓虹 冯振卿 
硝唑尼特是一种新的广谱抗肠道寄生虫药。它是自苯丙咪唑类药问世30多年来值得注意的一个新发展。它的广谱活性对许多种类的原虫,特别如肠道孢子形成类原虫,以及许多常见的蠕虫,包括绦虫、线虫和吸虫均有特效。进一步的临床和基础研究...
关键词：硝唑尼特 广谱抗肠道寄生虫药 原虫 蠕虫 绦虫 吸虫 线虫 
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