NITROREDUCTASE

作品数：16被引量：25H指数：3
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相关领域：医药卫生生物学更多>>
相关期刊：《Smart Molecules》《Chinese Journal of Chemistry》《Journal of Environmental Sciences》《Frontiers of Chemical Science and Engineering》更多>>
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A nitroreductase-responsive nanoprobe with homogeneous composition and high loading for preoperative non-invasive tumor imaging and intraoperative guidance
《Chinese Chemical Letters》2024年第7期313-318,共6页Jingqi Xin Shupeng Han Meichen Zheng Chenfeng Xu Zhongxi Huang Bin Wang Changmin Yu Feifei An Yu Ren 
supported by the National Natural Science Foundation of China(Nos.51903201,82172798);the Natural Science Foundation of Shaanxi Province(No.2023-YBSF-270);the Open Program of NHC Key Laboratory of Nuclear Medicine and Jiangsu Key Laboratory of Molecular Nuclear Medicine(No.KF202203);Horizontal Project of the First Affiliated Hospital of Xi'an Jiaotong University(No.202304174)。
Tumor microenvironment(TME)-activatable probes have been proven to effectively increase signal-tobackground ratios(SBRs)and improve the success rate of complete tumor resection.However,many fluorescence probes have to...
关键词：NITROREDUCTASE Tumor diagnosis Intraoperative guidance Self-assembly NANOPROBE 
An Efficient Probe for Bacterial Nitroreductase Imaging and Detection Based on NanoLuc-Furimazine Bioluminescent Pair
《Chinese Journal of Chemistry》2024年第12期1373-1380,共8页Ximeng Shi Yumeng Wang Jiaoyang Yu Yating Yang Zecheng Jin Hanghang Wang Dalei Wu Wei Chen Jianming Guo Yinan Zhang 
supported by the Program of the National Natural Science Foundation of China(No.22177052,Y.Zhang,No.82074136,J.Guo,No.82272340,W.Chen);the Joint Training Program for Graduated Students of the Institute of Translational Research and Drug Innovation(X.Shi).
Comprehensive SummaryThe detection of critical endogenous species, such as bacteria in microenvironments in the body, requires better imaging tools for visualization and monitoring of biological events. Bioluminescenc...
关键词：NITROREDUCTASE NanoLuc-furimazine Biosensors Analytical methods LUMINESCENCE Imaging agents 
Plasmonic nanostructures acting as a light-driven O_(2)-sensitive nitroreductase mimic for enhanced photochemical oxidation of para-aminothiophenol
《Nano Research》2023年第11期12697-12705,共9页Xinshuang Gao Jia-jia Zheng Hanbo Li Rui Cai Xingfa Gao Xiaochun Wu 
supported by the National Key Basic Research Program of China(No.2021YFA1202803);the National Natural Science Foundation of China(No.22072032);the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000)。
Nanozymes,as a novel form of enzyme mimics,have garnered considerable interest.Despite overcoming the main disadvantages of their natural analogs,they still face challenges such as restricted mimic types and low subst...
关键词：plasmonic nanostructure nanozyme NITROREDUCTASE para-nitrothiolphenol hot electron injection para-aminothiolphenol 
Evolving a novel red-emitting two-photon dye with optically tunable amino group for monitoring the degree of hypoxia during liver fibrosis
《Chinese Chemical Letters》2023年第5期480-483,共4页Xingxing Zhang Feiyu Yang Tianbing Ren Yingxin Zheng Xiao-Bing Zhang Lin Yuan 
supported by the National Natural Science Foundation of China(Nos.22074036,22004033,21877029);Special Funds for the Construction of Innovative Provinces in Hunan Province(No.2019RS1031)。
Two-photon imaging has attracted increasing attention owing to its deep tissue imaging capabilities.Therefore,many fluorophores have been developed to satisfy its requirements.However,long-wavelength emission fluoroph...
关键词：Fluorescent probes Two-photon imaging FLUOROPHORES NITROREDUCTASE HYPOXIA 
Engineering an asymmetric rhodamine dye suitable for developing ratiometric fluorescent probe
《Smart Molecules》2023年第1期91-96,共6页Feiyu Yang Peng Lu Tian-Bing Ren Xiao-Bing Zhang Lin Yuan 
supported by the National Natural Science Foundation of China(Project:22074036 and 22004033).
Fluorescent probes based on rhodamine skeleton are extensively used in biological imaging.However,the construction of ratiometric fluorescent probes based on the rhodamine skeleton without introducing additional fluor...
关键词：fluorescent probe imaging NITROREDUCTASE ratiometric probe RHODAMINE 
Inhibition of Escherichia coli nitroreductase by the constituents in Syzygium aromaticum
《Chinese Journal of Natural Medicines》2022年第7期506-517,共12页CHEN Lu CHEN Xi BAI Yue ZHAO Zi-Nan CAO Yun-Feng LIU Li-Kun JIANG Tao HOU Jie 
supported by the Natural Science Foundation of Liaoning Province(No.20180530025);the Innovative Entrepreneurship Program of High-level Talents in Dalian(No.2017RQ121);the Technology Innovation Foundation of Dalian(No.2020JJ26SN051);the National Natural Science Founding of China(No.82160739).
Gut bacterial nitroreductases play an important role in reduction of various nitroaromatic compounds to the corresponding N-nitroso compounds,hydroxylamines or aromatic amines,most of which are carcinogenic and mutage...
关键词：Gut bacterial nitroreductase EcNfsA inhibitor Syzygium aromaticum Anti-mutagenic activity 
The putative NAD(P)H Nitroreductase,Rv3131,is the Probable Activating Enzyme for Metronidazole in Mycobacterium Tuberculosis
《Biomedical and Environmental Sciences》2022年第7期652-656,共5页DONG Wen Zhu SHI Jin CHU Ping LIU Rong Mei WEN Shu An ZHANG Ting Ting PANG Yu LU Jie 
supported by National Natural Science Foundation of China [81401739]
Tuberculosis(TB),which is caused by the intracellular pathogen,Mycobacterium tuberculosis(Mtb),remains one of the deadliest infectious diseases worldwide,accounting for 1.45 million deaths in 2018[1].Thus,there is an ...
关键词：TUBERCULOSIS action LATENT 
Chemical screening reveals Ronidazole is a superior prodrug to Metronidazole for nitroreductase-induced cell ablation system in zebrafish larvae被引量：1
《Journal of Genetics and Genomics》2021年第12期1081-1090,共10页Siting Lai Ankita Kumari Jixiang Liu Yiyue Zhang Wenqing Zhang Kuangyu Yen Jin Xu 
supported by the National Natural Science Foundation of China(31771594,31970763);National Natural Science Foundation of China(NSFC)/Research Grants Council(RGC)Joint Research Scheme(31961160726);Guangdong Science and Technology Plan projects(2019A030317001)。
The Metronidazole(MTZ)/nitroreductase(NTR)-mediated cell ablation system is the most commonly used chemical-genetic cell ablation method in zebrafish. This system can specifically ablate target cells under spatial and...
关键词：MTZ Ronidazole NTR Cell ablation Regeneration ZEBRAFISH 
Recent progress in small molecule fluorescent probes for nitroreductase被引量：4
《Chinese Chemical Letters》2018年第10期1451-1455,共5页Wenjing Qin Chenchen Xu Yanfei Zhao Changmin Yu Sheng Shen Lin Li Wei Huang 
financially supported by the National Natural Science Foundation of China (Nos. 81672508 and 61505076);Jiangsu Provincial Foundation for Distinguished Young Scholars (No. BK20170041);Jiangsu Key Research and Development Program (No. BE2015699);Natural Science Foundation of Guangdong Province (No. 2017A030313299);State Key Laboratory of Pulp and Paper Engineering (No. 201706)
Nitroreductase（NTR） is a member of flavin-containing enzymes that exists widely in bacteria. Hypoxia,which is a characteristic of locally advanced solid tumors, resulting from an imbalance between oxygen consumption...
关键词：Probe Fluorescence NITROREDUCTASE Small molecule probes 
A simple umbelliferone based fluorescent probe for the detection of nitroreductase被引量：1
《Frontiers of Chemical Science and Engineering》2018年第2期311-314,共4页Adam C. Sedgwick Alex Hayden Barry Hill Steven D. Bull Robert B. P. Elmes Tony D. James 
A simple nitrobenzyl-umbelliferone （NCOU1） was synthesised containing a nitroreductase （NTR） trigger moiety. The presence of NTR, resulted in the fragmentation of the parent molecule and release of the highly emis...
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